Kytril and Mesna drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Kytril (granisetron hydrochloride) and Mesna (mesna). Common drug interactions include renal tubular acidosis among females and pyrexia among males.

The phase IV clinical study analyzes what interactions people have when they take Kytril and Mesna. It is created by eHealthMe based on reports of 82 people who take the same drugs from the FDA, and is updated regularly.

What is Kytril?

Kytril has active ingredients of granisetron hydrochloride. eHealthMe is studying from 10,766 Kytril users. Check the latest studies of Kytril.

What is Mesna?

Mesna has active ingredients of mesna. eHealthMe is studying from 9,647 Mesna users. Check the latest studies of Mesna.

On Jul, 17, 2026

82 people who take Kytril and Mesna together, and have interactions are studied.

What are the common drug interactions of Kytril and Mesna, by gender? *:

female:

Renal tubular acidosis (medical condition that involves an accumulation of acid in the body due to a failure of the kidneys)
Clonic convulsion (long lasting seizure)
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Eye movement disorder
Somnolence (a state of near-sleep, a strong desire for sleep)
Toxic encephalopathy (a degenerative neurologic disorder caused by exposure to toxic substances)
Unresponsive to stimuli
Accidental exposure
Anion gap increased
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)

male:

Pyrexia (fever)
Pain
Anaemia (lack of blood)
Dizziness
Anxiety
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Fatigue (feeling of tiredness)
Hodgkin's disease (cancer originating from white blood cells)
Night sweats (sweating in night)
Oral disorder (mouth disease)

What are the common drug interactions of Kytril and Mesna, by age (0-1 to 60+)? *:

0-1:

Abdominal distension
Cyst (a closed sac)
Diarrhoea
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Ileus paralytic (obstruction of the intestine due to paralysis of the intestinal muscles)
Markedly reduced food intake
Metastases to brain (cancer spreads to brain)
Vomiting

2-9:

Excessive eye blinking (excessive blinking is dry eyes)
Myoclonus (a brief, involuntary twitching of a muscle or a group of muscles)
Tic (a sudden, repetitive, nonrhythmic motor movement or vocalization involving discrete muscle groups)
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Tardive dyskinesia (a disorder that involves involuntary movements)
Trismus (reduced opening of the jaws)
Dyskinesia (abnormality or impairment of voluntary movement)

10-19:

Clonic convulsion (long lasting seizure)
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Eye movement disorder
Headache (pain in head)
Somnolence (a state of near-sleep, a strong desire for sleep)
Toxic encephalopathy (a degenerative neurologic disorder caused by exposure to toxic substances)
Unresponsive to stimuli
Acute respiratory failure
Arthritis bacterial (form of joint disorder that involves inflammation of one or more joints due to bacterial infection)
Bone marrow failure

20-29:

Pain
Anaemia (lack of blood)
Anxiety
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Dizziness
Fall
Fatigue (feeling of tiredness)
Febrile neutropenia (fever with reduced white blood cells)
Headache (pain in head)
Hodgkin's disease (cancer originating from white blood cells)

30-39:

Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Hypotension (abnormally low blood pressure)
Hypoxia (low oxygen in tissues)
Pyrexia (fever)
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Accidental exposure
Agitation (state of anxiety or nervous excitement)
Cardiac arrest
Coma (state of unconsciousness lasting more than six hours)
Encephalopathy (functioning of the brain is affected by some agent or condition)

40-49:

Renal failure acute (rapid kidney dysfunction)
Thrombocytopenia (decrease of platelets in blood)
Abdominal pain
Autonomic nervous system imbalance (autonomic nervous system is of net equal emphasis)
Blood pressure decreased
C-reactive protein increased
Chills (felling of cold)
Disease recurrence
Drug ineffective
Dyspnoea (difficult or laboured respiration)

50-59:

Hypotension (abnormally low blood pressure)
Diarrhoea
Headache (pain in head)
Insomnia (sleeplessness)
Oropharyngeal pain
Syncope (loss of consciousness with an inability to maintain postural tone)
Chills (felling of cold)
Epididymitis (pain in the scrotum or testicle)
Febrile neutropenia (fever with reduced white blood cells)
Joint swelling

60+:

Pyrexia (fever)
Neutropenia (an abnormally low number of neutrophils)
Pruritus (severe itching of the skin)
Purpura (purplish discoloration of the skin)
Renal impairment (severely reduced kidney function)
Sedation
Agitation (state of anxiety or nervous excitement)
Coma (state of unconsciousness lasting more than six hours)
Confusion
Cytomegalovirus infection

What are the existing conditions these people have? *

Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 11 people, 13.41%
Sarcoma (rare cancers that develop in the muscle, bone, nerves, cartilage, tendons, blood vessels and the fatty and fibrous tissues): 8 people, 9.76%
Pain: 7 people, 8.54%
Nausea (feeling of having an urge to vomit): 6 people, 7.32%
Nausea And Vomiting: 5 people, 6.10%
Bone Marrow Conditioning Regimen: 5 people, 6.10%

* Approximation only. Some reports may have incomplete information.

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