Lacosamide and Bactrim drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lacosamide (lacosamide) and Bactrim (sulfamethoxazole; trimethoprim). Common drug interactions include overdose among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Lacosamide and Bactrim. It is created by eHealthMe based on reports of 60 people who take the same drugs from the FDA, and is updated regularly.

What is Lacosamide?

Lacosamide has active ingredients of lacosamide. It is often used in epilepsy. eHealthMe is studying from 16,601 Lacosamide users. Check the latest studies of Lacosamide.

What is Bactrim?

Bactrim has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 89,117 Bactrim users. Check the latest studies of Bactrim.

On Jul, 10, 2026

60 people who take Lacosamide and Bactrim together, and have interactions are studied.

Lacosamide and Bactrim drug interactions.

What are the common drug interactions of Lacosamide and Bactrim, by gender? *:

female:

Overdose
Pleural effusion (water on the lungs)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Pulmonary oedema (fluid accumulation in the lungs)
Rash
Staphylococcal infection (an infection with staphylococcus bacteria)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Vomiting
Abdominal pain
Balance disorder

male:

Diarrhoea
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells)
Spinal pain (pain in spine)
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Back pain
Bacterial sepsis
Brain death
Hypotension (abnormally low blood pressure)
Nervous system disorder (a general class of medical conditions affecting the nervous system)

What are the common drug interactions of Lacosamide and Bactrim, by age (0-1 to 60+)? *:

0-1:

Bacterial sepsis
Brain death
Hypotension (abnormally low blood pressure)
Nervous system disorder (a general class of medical conditions affecting the nervous system)

2-9:

n/a

10-19:

n/a

20-29:

Hepatocellular injury (liver injury)
Jaundice cholestatic
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Blood alkaline phosphatase increased
Cardiac failure congestive
Cardiomyopathy (weakening of the heart muscle)
Enterococcal infection
Hepatic enzyme increased
Left ventricular hypertrophy (the thickening of the myocardium (muscle) of the left ventricle of the heart)
Pulmonary oedema (fluid accumulation in the lungs)

30-39:

Balance disorder
Disturbance in attention
Muscle spasms (muscle contraction)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Sleep disorder

40-49:

Erythema (redness of the skin)
Face oedema (swelling of face)
Vomiting
Abdominal pain upper
Alanine aminotransferase increased
Alopecia (absence of hair from areas of the body)
Aspartate aminotransferase increased
Diarrhoea
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Pleural effusion (water on the lungs)

50-59:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Drug ineffective
Abdominal pain
Abdominal pain upper
Constipation
Pneumonia
Pyrexia (fever)
Tremor (trembling or shaking movements in one or more parts of your body)
Cerebrovascular disorder (disease of brain)
Oedema peripheral (superficial swelling)

60+:

Pyrexia (fever)
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells)
Spinal pain (pain in spine)
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Malignant neoplasm progression (cancer tumour came back)
Confusional state
Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
Hemianopia homonymous (visual field defect involving either the two right or the two left halves of the visual fields of both eyes)
Richter's syndrome (hairy cell cancer changes in fast growing b cell cancer tumour)

What are the existing conditions these people have? *

Seizures (abnormal excessive or synchronous neuronal activity in the brain): 15 people, 25.00%
Depression: 8 people, 13.33%
Brain Neoplasm Malignant (brain cancer tumour): 8 people, 13.33%
Pain: 6 people, 10.00%
Fever: 6 people, 10.00%
Glioblastoma (most common and most aggressive malignant primary brain tumour in humans): 5 people, 8.33%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 4 people, 6.67%
Hyperlipidaemia (presence of excess lipids in the blood): 3 people, 5.00%
Constipation: 3 people, 5.00%

* Approximation only. Some reports may have incomplete information.

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