Lactulose and Acetazolamide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lactulose (lactulose) and Acetazolamide (acetazolamide). Common drug interactions include gastrointestinal disorder among females and toxic epidermal necrolysis among males.

The phase IV clinical study analyzes what interactions people have when they take Lactulose and Acetazolamide. It is created by eHealthMe based on reports of 85 people who take the same drugs from the FDA, and is updated regularly.

What is Lactulose?

Lactulose has active ingredients of lactulose. It is often used in constipation. eHealthMe is studying from 46,960 Lactulose users. Check the latest studies of Lactulose.

What is Acetazolamide?

Acetazolamide has active ingredients of acetazolamide. It is often used in pseudotumor cerebri. eHealthMe is studying from 6,178 Acetazolamide users. Check the latest studies of Acetazolamide.

On Jul, 23, 2026

85 people who take Lactulose and Acetazolamide together, and have interactions are studied.

Lactulose and Acetazolamide drug interactions.

What are the common drug interactions of Lactulose and Acetazolamide, by gender? *:

female:

Gastrointestinal disorder (functional problems of gastrointestinal tract)
Hypotension (abnormally low blood pressure)
Hypoxia (low oxygen in tissues)
Insomnia (sleeplessness)
Migraine (headache)
Muscle spasticity (tight or stiff muscles and an inability to control those muscles)
Nervousness
Pneumonia
Pyrexia (fever)
Urinary tract infection

male:

Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Hepatic failure (liver failure)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haematoma (collection of blood outside the blood vessels)
Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid)
Pulmonary hypertension (increase in blood pressure in the lung artery)
Renal failure acute (rapid kidney dysfunction)
Septic shock (shock due to blood infection)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

What are the common drug interactions of Lactulose and Acetazolamide, by age (0-1 to 60+)? *:

0-1:

Alanine aminotransferase increased
Circulatory collapse
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Hepatic failure (liver failure)
Lactic acidosis (low ph in body tissues)
Renal failure (kidney dysfunction)

2-9:

Alanine aminotransferase increased
Anticonvulsant drug level increased
Aspartate aminotransferase increased
Asthenia (weakness)
Bilirubin conjugated increased
Blood alkaline phosphatase increased
Blood bilirubin increased
Blood creatine phosphokinase increased
Blood pressure decreased
Body temperature decreased

10-19:

n/a

20-29:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Suicide attempt
Abdominal infection
Abdominal pain upper
Acidosis (build-up of carbon dioxide in the blood)
Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)
Asthenia (weakness)
Back pain
Blood cholesterol increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

30-39:

Pneumonia bacterial (pneumonia associated with bacterial infection)
Asthenia (weakness)
Cholecystitis acute (rapid infection of gallbladder)
Dyspnoea (difficult or laboured respiration)
Gastrointestinal necrosis (destruction of gastrointestinal organ)
General physical health deterioration (weak health status)
Hypercapnia (too much smoke)
Intestinal perforation (complete penetration of the wall of the intestine)
Liver disorder (liver diseases)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)

40-49:

Hepatic failure (liver failure)

50-59:

Renal failure (kidney dysfunction)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Alanine aminotransferase increased
Aspartate aminotransferase increased
Bacteraemia (presence of bacteria in the blood)
Burkholderia test positive
Deafness transitory (deafness temporary)
Depression
Ear infection
Exfoliative rash (scaly red generalized skin rash)

60+:

Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Somnolence (a state of near-sleep, a strong desire for sleep)
Colitis (inflammation of colon)
Respiratory failure (inadequate gas exchange by the respiratory system)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Tachypnoea (a condition of rapid breathing over 20 per minute)
Back pain
Burkholderia test positive
Confusional state

What are the existing conditions these people have? *

Stress And Anxiety: 19 people, 22.35%
High Blood Pressure: 18 people, 21.18%
Fever: 14 people, 16.47%
Diarrhea: 13 people, 15.29%
Depression: 12 people, 14.12%
Sedation: 11 people, 12.94%
Pneumonia: 11 people, 12.94%
Pain: 11 people, 12.94%
Ards (Acute Respiratory Distress Syndrome) (sudden failure of the respiratory (breathing) system): 10 people, 11.76%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 10 people, 11.76%

* Approximation only. Some reports may have incomplete information.

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