Lactulose and Co-codamol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lactulose (lactulose) and Co-codamol (acetaminophen; codeine phosphate). Common drug interactions include metastases to liver among females and gastrointestinal haemorrhage among males.

The phase IV clinical study analyzes what interactions people have when they take Lactulose and Co-codamol. It is created by eHealthMe based on reports of 89 people who take the same drugs from the FDA, and is updated regularly.

What is Lactulose?

Lactulose has active ingredients of lactulose. It is often used in constipation. eHealthMe is studying from 46,960 Lactulose users. Check the latest studies of Lactulose.

What is Co-codamol?

Co-codamol has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. eHealthMe is studying from 2,364 Co-codamol users. Check the latest studies of Co-codamol.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

89 people who take Lactulose and Co-codamol together, and have interactions are studied.

Lactulose and Co-codamol drug interactions.

What are the common drug interactions of Lactulose and Co-Codamol, by gender? *:

female:

Metastases to liver (cancer spreads to liver)
Small cell lung cancer metastatic (lung cancer spreads to other body parts)
Abdominal tenderness
Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)
Age-related macular degeneration
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anal fissure
Anaphylactic reaction (serious allergic reaction)
Ankle fracture
Aortic aneurysm rupture (enlarged aortic artery rapture caused by a weakening of the artery wall)

male:

Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Lower respiratory tract infection
Respiratory failure (inadequate gas exchange by the respiratory system)
Sudden death
Vomiting
Alanine aminotransferase increased
Blood bilirubin increased
Dyspnoea (difficult or laboured respiration)
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)

What are the common drug interactions of Lactulose and Co-Codamol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal pain
Anal fissure
Faecal incontinence (a lack of control over passing stool)
Functional gastrointestinal disorder (functional problem in separate organs of gastrointestinal system)
Haematochezia (passage of stools containing blood)
Haemoglobin decreased
Haemorrhoidal haemorrhage (bleeding from the haemorrhoids)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Platelet count decreased
Rectal haemorrhage (bleeding from anus)

30-39:

Hepatitis (inflammation of the liver)
Tenderness (pain or discomfort when an affected area is touched)
Abdominal pain
Abdominal tenderness
Blood magnesium decreased
Confusion
Dysphagia (a condition in which swallowing is difficult or painful)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Hallucination (an experience involving the perception of something not present)
Headache (pain in head)

40-49:

Hypoxia (low oxygen in tissues)
Status epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure)
Cardiac arrest

50-59:

Abdominal pain
Ankle fracture
Change of bowel habit
Metastatic malignant melanoma (spreadable cancer tumour of melanine)
Myalgia (muscle pain)
Postoperative wound infection
Sleep disorder

60+:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Hypernatraemia (an abnormally high plasma concentration of sodium ions)
Swollen tongue (swelling of tongue)
Varices oesophageal (enlarged and swollen veins at the bottom of the oesophagus, near the stomach)
Haematemesis (vomiting of blood)
Malaise (a feeling of general discomfort or uneasiness)
Melaena (the passage of black, tarry stools)
Rash
Lower respiratory tract infection
Blood alkaline phosphatase increased

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 8 people, 8.99%
Osteoporosis (bones weak and more likely to break): 7 people, 7.87%
Lower Respiratory Tract Infection: 7 people, 7.87%
High Blood Cholesterol: 7 people, 7.87%
Dementia Alzheimer's Type (loss of mental ability with alzheimer's symptom): 7 people, 7.87%
Urinary Tract Infection: 6 people, 6.74%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 6 people, 6.74%
Chest Pain: 6 people, 6.74%
Anaemia (lack of blood): 6 people, 6.74%
Abdominal Pain Upper: 6 people, 6.74%

* Approximation only. Some reports may have incomplete information.

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