Lamotrigine and Acth drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lamotrigine (lamotrigine) and Acth (corticotropin). Common drug interactions include diabetes mellitus among females and multiple-drug resistance among males.

The phase IV clinical study analyzes what interactions people have when they take Lamotrigine and Acth. It is created by eHealthMe based on reports of 40 people who take the same drugs from the FDA, and is updated regularly.

What is Lamotrigine?

Lamotrigine has active ingredients of lamotrigine. It is often used in bipolar disorder. eHealthMe is studying from 76,638 Lamotrigine users. Check the latest studies of Lamotrigine.

What is Acth?

Acth has active ingredients of corticotropin. eHealthMe is studying from 5,402 Acth users. Check the latest studies of Acth.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

40 people who take Lamotrigine and Acth together, and have interactions are studied.

What are the common drug interactions of Lamotrigine and Acth, by gender? *:

female:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Drug ineffective
Fatigue (feeling of tiredness)
Gait disturbance
Inflammation
Insomnia (sleeplessness)
Laziness
Pain
Sluggishness (lacking alertness)
Somnolence (a state of near-sleep, a strong desire for sleep)

male:

Multiple-drug resistance
Decreased appetite
Skin hypopigmentation (loss of skin colour)
Death
Depression
Nausea (feeling of having an urge to vomit)
Pancreatitis (inflammation of pancreas)
Somnolence (a state of near-sleep, a strong desire for sleep)
Dehydration (dryness resulting from the removal of water)
Drug ineffective

What are the common drug interactions of Lamotrigine and Acth, by age (0-1 to 60+)? *:

0-1:

Multiple-drug resistance
Pneumonia
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Skin hypopigmentation (loss of skin colour)
Astigmatism (refractive error of the eye in which parallel rays of light from an external source do not converge on a single focal point on the retina)
Balance disorder
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Drug ineffective
Eye pain
Myopia (difficult to see objects that are far away)

2-9:

Agitation (state of anxiety or nervous excitement)
Death
Drug ineffective
Increased bronchial secretion
Insomnia (sleeplessness)
Multiple-drug resistance
Secretion discharge
Seizure (abnormal excessive or synchronous neuronal activity in the brain)

10-19:

Drug ineffective
Decreased appetite
Dehydration (dryness resulting from the removal of water)
Rash
Fatigue (feeling of tiredness)
Multiple-drug resistance
Partial seizures (seizures which affect only a part of the brain at onset)
Discomfort
Insomnia (sleeplessness)
Nausea (feeling of having an urge to vomit)

20-29:

Intentional self-injury
Depression
Fatigue (feeling of tiredness)
Pancreatitis (inflammation of pancreas)
Somnolence (a state of near-sleep, a strong desire for sleep)

30-39:

n/a

40-49:

Injection site pruritus (severe itching at injection site)
Injection site swelling

50-59:

Nausea (feeling of having an urge to vomit)
Allergy to arthropod sting
Muscle tightness
Palpitations (feelings or sensations that your heart is pounding or racing)
Skin discolouration (change of skin colour)
Skin infection
Pain in extremity
Acute respiratory failure
Arthropod sting (arthropod bite)
Cellulitis (infection under the skin)

60+:

n/a

What are the existing conditions these people have? *

Seizures (abnormal excessive or synchronous neuronal activity in the brain): 8 people, 20.00%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 6 people, 15.00%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 5 people, 12.50%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 10.00%
Pemphigoid (tense blisters on the skin): 4 people, 10.00%
Partial Seizures (seizures which affect only a part of the brain at onset): 4 people, 10.00%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 4 people, 10.00%
Iridocyclitis (inflammation of the iris and ciliary body of the eye): 4 people, 10.00%
Infantile Spasms: 4 people, 10.00%
Sarcoidosis (an inflammatory disease that affects multiple organs in the body, but mostly the lungs and lymph glands): 3 people, 7.50%

* Approximation only. Some reports may have incomplete information.

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