Lamotrigine and Macrobid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lamotrigine (lamotrigine) and Macrobid (nitrofurantoin; nitrofurantoin, macrocrystalline). Common drug interactions include disturbance in attention among females and cardiac disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Lamotrigine and Macrobid. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Lamotrigine?

Lamotrigine has active ingredients of lamotrigine. It is often used in bipolar disorder. eHealthMe is studying from 76,638 Lamotrigine users. Check the latest studies of Lamotrigine.

What is Macrobid?

Macrobid has active ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 9,215 Macrobid users. Check the latest studies of Macrobid.

On Jul, 28, 2026

30 people who take Lamotrigine and Macrobid together, and have interactions are studied.

Lamotrigine and Macrobid drug interactions.

What are the common drug interactions of Lamotrigine and Macrobid, by gender? *:

female:

Disturbance in attention
Eating disorder
Emotional distress
Hepatic steatosis (fatty liver disease)
Hospitalisation
Hypersomnia (excessive daytime sleepiness (eds))
Illusion
Injury
Leukocytosis (increased white blood cells)
Ligament sprain (ligament stretched)

male:

Cardiac disorder
Influenza like illness
Blood osmolarity decreased
Cardiac failure congestive
Cardiomyopathy (weakening of the heart muscle)
Chest pain
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Constipation
Cough
Decreased appetite

What are the common drug interactions of Lamotrigine and Macrobid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal pain upper
Dehydration (dryness resulting from the removal of water)
Fall
Localised infection (infection at the single location)
Oropharyngeal pain
Sneezing
Toothache (tooth pain)
Diarrhoea
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Arthralgia (joint pain)

40-49:

Asthenia (weakness)
Malaise (a feeling of general discomfort or uneasiness)
Pain
Pruritus (severe itching of the skin)
Accident
Affective disorder (mental disorder)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arthralgia (joint pain)
Arthritis infective (purulent invasion of a joint by an infectious agent which produces arthritis)

50-59:

Pneumonia
Renal failure (kidney dysfunction)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Arthralgia (joint pain)
Bone disorder
Chronic kidney disease
Crepitations (noises are produced by the rubbing of parts one against the other)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Joint crepitation

60+:

Body temperature increased
Fatigue (feeling of tiredness)
Abdominal discomfort
Abdominal pain
Abdominal pain upper
Alanine aminotransferase increased
Anaemia (lack of blood)
Ataxia (loss of full control of bodily movements)
Atrioventricular block first degree (heart block first degree)
Balanitis (inflammation of the glands penis)

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 6 people, 20.00%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 5 people, 16.67%
Migraine (headache): 4 people, 13.33%
Hyperkalemia (damage to or disease of the kidney): 3 people, 10.00%
High Blood Pressure: 3 people, 10.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 10.00%
Depression: 3 people, 10.00%
Pain: 2 people, 6.67%
Nausea (feeling of having an urge to vomit): 2 people, 6.67%
Immunodeficiency Common Variable: 2 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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