Lamotrigine and Nucynta drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lamotrigine (lamotrigine) and Nucynta (tapentadol hydrochloride). Common drug interactions include blood potassium decreased among females and fall among males.

The phase IV clinical study analyzes what interactions people have when they take Lamotrigine and Nucynta. It is created by eHealthMe based on reports of 74 people who take the same drugs from the FDA, and is updated regularly.

What is Lamotrigine?

Lamotrigine has active ingredients of lamotrigine. It is often used in bipolar disorder. eHealthMe is studying from 76,638 Lamotrigine users. Check the latest studies of Lamotrigine.

What is Nucynta?

Nucynta has active ingredients of tapentadol hydrochloride. It is often used in pain. eHealthMe is studying from 31,818 Nucynta users. Check the latest studies of Nucynta.

On Aug, 12, 2026

74 people who take Lamotrigine and Nucynta together, and have interactions are studied.

Lamotrigine and Nucynta drug interactions.

What are the common drug interactions of Lamotrigine and Nucynta, by gender? *:

female:

Blood potassium decreased
Blood pressure decreased
Blood pressure increased
Feeling of despair
Hysterectomy
Intervertebral disc degeneration (spinal disc degeneration)
Kidney infection
Limb injury
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Psychiatric symptom

male:

Fall
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Loss of consciousness
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Muscle spasms (muscle contraction)
Renal failure (kidney dysfunction)
Cerebral ischaemia (insufficient blood flow to the brain to meet metabolic demand)
Demyelination (loss of the myelin covering of some nerve fibres resulting in their impaired function)
Diarrhoea
Hypersomnia (excessive daytime sleepiness (eds))

What are the common drug interactions of Lamotrigine and Nucynta, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Insomnia (sleeplessness)
Palpitations (feelings or sensations that your heart is pounding or racing)
Supraventricular tachycardia (rapid heart rhythm originating at or above the atrioventricular node)
Tremor (trembling or shaking movements in one or more parts of your body)

30-39:

Abnormal behaviour

40-49:

Drug ineffective
General physical health deterioration (weak health status)
Suicidal ideation
Borderline personality disorder
Cervical spinal stenosis (narrowing of the spinal canal in the neck)
Depression
Intervertebral disc protrusion (spinal disc protrusion)
Myalgia (muscle pain)
Disability
Fatigue (feeling of tiredness)

50-59:

Joint swelling
Anxiety
Arthropathy
Burning sensation
Chronic kidney disease
Drug ineffective
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Nodule (a growth of abnormal tissue)
Oedema peripheral (superficial swelling)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)

60+:

Fall
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Loss of consciousness
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Muscle spasms (muscle contraction)
Renal failure (kidney dysfunction)
Cerebral ischaemia (insufficient blood flow to the brain to meet metabolic demand)
Demyelination (loss of the myelin covering of some nerve fibres resulting in their impaired function)
Diarrhoea
Hypersomnia (excessive daytime sleepiness (eds))

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 32 people, 43.24%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 18 people, 24.32%
Stress And Anxiety: 12 people, 16.22%
Depression: 11 people, 14.86%
High Blood Pressure: 10 people, 13.51%
Fibromyalgia (a long-term condition which causes pain all over the body): 10 people, 13.51%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 10.81%
Nausea (feeling of having an urge to vomit): 7 people, 9.46%
High Blood Cholesterol: 6 people, 8.11%
Migraine (headache): 5 people, 6.76%

* Approximation only. Some reports may have incomplete information.

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