Lamotrigine and Questran drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lamotrigine (lamotrigine) and Questran (cholestyramine). Common drug interactions include bile acid malabsorption among females and confusional state among males.

The phase IV clinical study analyzes what interactions people have when they take Lamotrigine and Questran. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Lamotrigine?

Lamotrigine has active ingredients of lamotrigine. It is often used in bipolar disorder. eHealthMe is studying from 76,638 Lamotrigine users. Check the latest studies of Lamotrigine.

What is Questran?

Questran has active ingredients of cholestyramine. It is often used in diarrhea. eHealthMe is studying from 4,490 Questran users. Check the latest studies of Questran.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

18 people who take Lamotrigine and Questran together, and have interactions are studied.

Lamotrigine and Questran drug interactions.

What are the common drug interactions of Lamotrigine and Questran, by gender? *:

female:

Bile acid malabsorption
Functional gastrointestinal disorder (functional problem in separate organs of gastrointestinal system)
Abdominal pain
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Drug ineffective
Therapeutic response decreased (less preventive response)
Blood magnesium decreased
Blood potassium decreased
Nausea (feeling of having an urge to vomit)
Palpitations (feelings or sensations that your heart is pounding or racing)

male:

Confusional state
Acute stress disorder
Cerebral small vessel ischaemic disease (inadequate blood supply to small blood vessel of brain)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Depression
Disturbance in attention
Drug ineffective
Encephalopathy (functioning of the brain is affected by some agent or condition)
Fall
Headache (pain in head)

What are the common drug interactions of Lamotrigine and Questran, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Bile acid malabsorption
Functional gastrointestinal disorder (functional problem in separate organs of gastrointestinal system)
Abdominal pain
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Drug ineffective
Therapeutic response decreased (less preventive response)

40-49:

Acute stress disorder
Adjustment disorder
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anxiety
Back pain
Balance disorder
Basal ganglion degeneration (loss of brain tissue in the cortex, or outer layer of the brain)
Carotid arteriosclerosis (plaque deposition in artery)
Cerebellar atrophy (degeneration of the section of the brain responsible for balance, voluntary muscle movements)
Cerebral small vessel ischaemic disease (inadequate blood supply to small blood vessel of brain)

50-59:

Pneumonia pneumococcal (pneumococcal pneumonia is a common but serious infection and inflammation of the lungs)

60+:

Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Altered state of consciousness (altered state of mind)
Thrombocytopenia (decrease of platelets in blood)
Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart)
Cellulitis (infection under the skin)
Confusional state
Embolism (obstruction of an artery, typically by a clot of blood or an air bubble)
Neutropenia (an abnormally low number of neutrophils)
Pyrexia (fever)
Renal failure acute (rapid kidney dysfunction)

What are the existing conditions these people have? *

Depression: 13 people, 72.22%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 11 people, 61.11%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 10 people, 55.56%
Bile Acid Malabsorption: 10 people, 55.56%
Myoclonic Epilepsy (type of epilepsy with quick little jerks of the arms, shoulder, or occasionally the legs): 7 people, 38.89%
Constipation: 4 people, 22.22%
Tinea Infection (fungal skin infection): 3 people, 16.67%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 3 people, 16.67%
Oedema Peripheral (superficial swelling): 3 people, 16.67%
Multiple Myeloma (cancer of the plasma cells): 3 people, 16.67%

* Approximation only. Some reports may have incomplete information.

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