Lamotrigine and Valacyclovir hydrochloride drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lamotrigine (lamotrigine) and Valacyclovir hydrochloride (valacyclovir hydrochloride). Common drug interactions include gallbladder non-functioning among females and cholangitis among males.

The phase IV clinical study analyzes what interactions people have when they take Lamotrigine and Valacyclovir hydrochloride. It is created by eHealthMe based on reports of 72 people who take the same drugs from the FDA, and is updated regularly.

What is Lamotrigine?

Lamotrigine has active ingredients of lamotrigine. It is often used in bipolar disorder. eHealthMe is studying from 76,638 Lamotrigine users. Check the latest studies of Lamotrigine.

What is Valacyclovir hydrochloride?

Valacyclovir hydrochloride has active ingredients of valacyclovir hydrochloride. It is often used in herpes zoster. eHealthMe is studying from 12,929 Valacyclovir hydrochloride users. Check the latest studies of Valacyclovir hydrochloride.



On Aug, 01, 2026

72 people who take Lamotrigine and Valacyclovir hydrochloride together, and have interactions are studied.

Lamotrigine and Valacyclovir hydrochloride drug interactions.

What are the common drug interactions of Lamotrigine and Valacyclovir Hydrochloride, by gender? *:

female:

  1. Gallbladder non-functioning
  2. Glomerular filtration rate decreased
  3. High density lipoprotein increased
  4. Homeless
  5. Lipodystrophy acquired (a regional loss of subcutaneous adipose tissue which usually starts in the face, extends downward acquired)
  6. Loss of employment
  7. Mean cell haemoglobin concentration decreased (less concentration of haemoglobin in a given volume of packed red blood cells)
  8. Myalgia (muscle pain)
  9. Obesity (having too much body fat)
  10. Oropharyngeal pain

male:

  1. Cholangitis (infection of the bile duct)
  2. Drug ineffective
  3. Fatigue (feeling of tiredness)
  4. Hypersomnia (excessive daytime sleepiness (eds))
  5. Lethargy (tiredness)
  6. Plasma cell myeloma (cancer that begins in plasma cells)
  7. Renal failure (kidney dysfunction)
  8. Chest pain
  9. Diaphragmatic disorder
  10. Feeling hot

What are the common drug interactions of Lamotrigine and Valacyclovir Hydrochloride, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Abdominal pain
  2. Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
  3. Back pain
  4. Breast tenderness
  5. Decreased appetite
  6. Device dislocation
  7. Dizziness
  8. Dyspareunia (painful sexual intercourse)
  9. Dyspnoea (difficult or laboured respiration)
  10. Fatigue (feeling of tiredness)

30-39:

  1. Abortion spontaneous (naturally occurring miscarriage)
  2. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
  3. Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
  4. Dyspnoea (difficult or laboured respiration)
  5. Hallucination (an experience involving the perception of something not present)
  6. Malaise (a feeling of general discomfort or uneasiness)
  7. Maternal exposure during pregnancy (use of substance during pregnancy)
  8. Pain
  9. Vomiting
  10. Chest pain

40-49:

  1. Hypertension (high blood pressure)
  2. Hypoaesthesia (reduced sense of touch or sensation)
  3. Hypokinesia (decreased bodily movement)
  4. Memory impairment
  5. Migraine (headache)
  6. Muscle spasms (muscle contraction)
  7. Muscular weakness (muscle weakness)
  8. Nausea (feeling of having an urge to vomit)
  9. Neuralgia (pain in one or more nerves)
  10. Sensory disturbance (sense disturbance)

50-59:

  1. Dizziness
  2. Drug ineffective
  3. Fatigue (feeling of tiredness)
  4. Hypersomnia (excessive daytime sleepiness (eds))
  5. Lethargy (tiredness)
  6. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  7. Anxiety
  8. Bone density decreased
  9. Chronic kidney disease
  10. Diarrhoea

60+:

  1. Bronchopulmonary aspergillosis (lung disorder caused by aspergillus fungi)
  2. Pyrexia (fever)
  3. Hepatic lesion
  4. Lung disorder (lung disease)
  5. Lung neoplasm (tumour of lung)
  6. Splenomegaly (enlargement of spleen)
  7. Biliary tract infection
  8. Dermatitis allergic (inflammation of the skin due allergic reaction)
  9. Diarrhoea
  10. Dry skin

What are the existing conditions these people have? *

  1. Depression: 21 people, 29.17%
  2. Pain: 9 people, 12.50%
  3. Stress And Anxiety: 6 people, 8.33%
  4. Hiv Infection: 6 people, 8.33%
  5. Herpes Virus Infection: 6 people, 8.33%
  6. High Blood Pressure: 6 people, 8.33%
  7. Nausea (feeling of having an urge to vomit): 6 people, 8.33%
  8. Multiple Myeloma (cancer of the plasma cells): 5 people, 6.94%
  9. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 6.94%
  10. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 6.94%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Lamotrigine and Valacyclovir hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Lamotrigine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Valacyclovir hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Lamotrigine and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Valacyclovir hydrochloride and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on lamotrigine and valacyclovir hydrochloride (the active ingredients of Lamotrigine and Valacyclovir hydrochloride, respectively), and Lamotrigine and Valacyclovir hydrochloride (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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