Lanoxin and Xigris drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lanoxin (digoxin) and Xigris (drotrecogin alfa (activated)). Common drug interactions include activated partial thromboplastin time prolonged among females and activated partial thromboplastin time prolonged among males.

The phase IV clinical study analyzes what interactions people have when they take Lanoxin and Xigris. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Lanoxin?

Lanoxin has active ingredients of digoxin. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 21,852 Lanoxin users. Check the latest studies of Lanoxin.

What is Xigris?

Xigris has active ingredients of drotrecogin alfa (activated). eHealthMe is studying from 3,542 Xigris users. Check the latest studies of Xigris.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

11 people who take Lanoxin and Xigris together, and have interactions are studied.

What are the common drug interactions of Lanoxin and Xigris, by gender? *:

female:

Activated partial thromboplastin time prolonged
Haematocrit decreased
International normalised ratio increased
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Prothrombin time shortened
Thrombocytopenia (decrease of platelets in blood)

male:

Activated partial thromboplastin time prolonged
Haematocrit decreased
Respiratory failure (inadequate gas exchange by the respiratory system)
Ventricular dysfunction (heart dysfunction)
Waterhouse-friderichsen syndrome (adrenal gland failure due to bleeding into the adrenal glands, caused by severe bacterial infection)
Activated partial thromboplastin time shortened
Blood fibrinogen increased
Blood urea increased
Faecal occult blood positive
International normalised ratio decreased

What are the common drug interactions of Lanoxin and Xigris, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Cardiac failure
Cerebral infarction (less blood supply to brain resulting tissue damage)
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Ejection fraction decreased (systolic heart failure)
Intraventricular haemorrhage (intraventricular bleeding)
Ventricular dysfunction (heart dysfunction)
Waterhouse-friderichsen syndrome (adrenal gland failure due to bleeding into the adrenal glands, caused by severe bacterial infection)
Activated partial thromboplastin time prolonged
Activated partial thromboplastin time shortened
Haematocrit decreased

20-29:

n/a

30-39:

n/a

40-49:

Activated partial thromboplastin time prolonged
Blood urea increased
Faecal occult blood positive
Haematocrit decreased
Haemoglobin decreased
Platelet count decreased
White blood cell count increased
Bacterial infection
Blood creatine increased
Blood creatinine increased

50-59:

n/a

60+:

Activated partial thromboplastin time prolonged
Haematocrit decreased
Thrombocytopenia (decrease of platelets in blood)
International normalised ratio increased
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Platelet count decreased
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Prothrombin time shortened
Renal failure acute (rapid kidney dysfunction)
Respiratory failure (inadequate gas exchange by the respiratory system)

What are the existing conditions these people have? *

Sepsis (a severe blood infection that can lead to organ failure and death): 3 people, 27.27%
Meningitis Meningococcal (a bacterial infection of the membranes covering the brain and spinal cord (meninges)): 2 people, 18.18%
Septic Shock (shock due to blood infection): 1 person, 9.09%
Psychotic Disorder: 1 person, 9.09%
Meningococcal Infection (a bacterial infection caused by meningococcal bacteria): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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