Lantus and Efudex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lantus (insulin glargine recombinant) and Efudex (fluorouracil). Common drug interactions include hiatus hernia among females and abdominal discomfort among males.

The phase IV clinical study analyzes what interactions people have when they take Lantus and Efudex. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Lantus?

Lantus has active ingredients of insulin glargine recombinant. It is often used in diabetes. eHealthMe is studying from 191,782 Lantus users. Check the latest studies of Lantus.

What is Efudex?

Efudex has active ingredients of fluorouracil. It is often used in actinic keratosis. eHealthMe is studying from 1,391 Efudex users. Check the latest studies of Efudex.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

11 people who take Lantus and Efudex together, and have interactions are studied.

What are the common drug interactions of Lantus and Efudex, by gender? *:

female:

Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Hyperglycaemia (high blood sugar)
Hyperlipidaemia (presence of excess lipids in the blood)
Hypersensitivity
Hypopnoea (decrease in the breathing rate)
Impaired healing
Injury
Insomnia (sleeplessness)
Lentigo (a small pigmented spot on the skin with a clearly-defined edge, surrounded by normal-appearing skin)
Lip ulceration (ulcer of lip)

male:

Abdominal discomfort
Abdominal pain
Essential hypertension (primary hypertension)
Gout (uric acid crystals building up in the body)
Haematocrit decreased
Haemoglobin decreased
Herpes simplex (herpes simplex is a common viral infection)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Hypercholesterolaemia (high levels of cholesterol in the blood)
Hypotension (abnormally low blood pressure)

What are the common drug interactions of Lantus and Efudex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Hepatic mass
Hepatic steatosis (fatty liver disease)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Hyperglycaemia (high blood sugar)
Hyperlipidaemia (presence of excess lipids in the blood)
Hypersensitivity
Hypopnoea (decrease in the breathing rate)
Impaired healing
Injury
Insomnia (sleeplessness)

60+:

Abdominal discomfort
Abdominal pain
Essential hypertension (primary hypertension)
Gout (uric acid crystals building up in the body)
Haematocrit decreased
Haemoglobin decreased
Herpes simplex (herpes simplex is a common viral infection)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Hypercholesterolaemia (high levels of cholesterol in the blood)
Hypotension (abnormally low blood pressure)

What are the existing conditions these people have? *

Breast Cancer Female: 5 people, 45.45%
Pain: 4 people, 36.36%
High Blood Pressure: 3 people, 27.27%
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it): 2 people, 18.18%
Asthma: 2 people, 18.18%
Prostate Cancer: 2 people, 18.18%
Constipation: 2 people, 18.18%
Depression: 2 people, 18.18%
Indigestion: 2 people, 18.18%
Idiopathic Thrombocytopenic Purpura (Itp) (bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting): 2 people, 18.18%

* Approximation only. Some reports may have incomplete information.

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