Lantus and Rezulin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lantus (insulin glargine recombinant) and Rezulin (troglitazone). Common drug interactions include vomiting among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Lantus and Rezulin. It is created by eHealthMe based on reports of 50 people who take the same drugs from the FDA, and is updated regularly.

What is Lantus?

Lantus has active ingredients of insulin glargine recombinant. It is often used in diabetes. eHealthMe is studying from 191,782 Lantus users. Check the latest studies of Lantus.

What is Rezulin?

Rezulin has active ingredients of troglitazone. eHealthMe is studying from 8,764 Rezulin users. Check the latest studies of Rezulin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

50 people who take Lantus and Rezulin together, and have interactions are studied.

What are the common drug interactions of Lantus and Rezulin, by gender? *:

female:

Vomiting
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Gastritis (inflammation of stomach)
Hypophagia (reduced food intake)
Abdominal pain upper
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bradycardia (abnormally slow heart action)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Dyspnoea exertional (breathlessness or shortness of breath)

male:

Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Weight increased
Acute myocardial infarction (acute heart attack)
Anxiety
Areflexia (absence of a reflex)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Cardiomegaly (increased size of heart than normal)
Cataract (clouding of the lens inside the eye)

What are the common drug interactions of Lantus and Rezulin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Angiopathy (generic term for a disease of the blood vessels)
Diabetes mellitus inadequate control
Diabetic foot
Diabetic foot infection
Diabetic gangrene
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Diabetic vascular disorder (diseases of the blood vessels due to diabetes)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Necrosis (the death of body tissue)
Obesity (having too much body fat)

40-49:

Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Chest pain
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Dehydration (dryness resulting from the removal of water)
Diabetic hyperosmolar coma (diabetes coma due to extremely high blood sugar (glucose) levels; extreme lack of water (dehydration))
Diarrhoea
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Dyspnoea (difficult or laboured respiration)

50-59:

Chronic kidney disease
Renal failure (kidney dysfunction)
Anxiety
Depression
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Nephropathy (damage to or disease of a kidney)
Renal impairment (severely reduced kidney function)

60+:

Cardiac failure congestive
Decreased appetite
Hyperkalaemia (damage to or disease of the kidney)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Hypotension (abnormally low blood pressure)
Hypovolaemia (a decreased volume of circulating blood in the body)
International normalised ratio increased
Loss of consciousness
Multiple injuries
Pulmonary oedema (fluid accumulation in the lungs)

What are the existing conditions these people have? *

Type 2 Diabetes: 23 people, 46.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 12.00%
Depression: 6 people, 12.00%
High Blood Pressure: 5 people, 10.00%
High Blood Cholesterol: 3 people, 6.00%
Cardiac Failure Congestive: 3 people, 6.00%

* Approximation only. Some reports may have incomplete information.

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