1. Home
  2. Analysis
  3. Leflunomide
  4. Aubagio

Leflunomide and Aubagio drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Leflunomide (leflunomide) and Aubagio (teriflunomide). Common drug interactions include respiratory tract infection among females and pain among males.

The phase IV clinical study analyzes what interactions people have when they take Leflunomide and Aubagio. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Leflunomide?

Leflunomide has active ingredients of leflunomide. It is often used in rheumatoid arthritis. eHealthMe is studying from 82,105 Leflunomide users. Check the latest studies of Leflunomide.

What is Aubagio?

Aubagio has active ingredients of teriflunomide. It is often used in multiple sclerosis. eHealthMe is studying from 50,041 Aubagio users. Check the latest studies of Aubagio.

On Jul, 14, 2026

20 people who take Leflunomide and Aubagio together, and have interactions are studied.

Leflunomide and Aubagio drug interactions.

What are the common drug interactions of Leflunomide and Aubagio, by gender? *:

female:

  1. Respiratory tract infection
  2. Abdominal pain upper
  3. Balance disorder
  4. Blood pressure increased
  5. Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
  6. Csf pressure increased
  7. Cystitis (inflammation of the wall of the bladder)
  8. Depressed mood
  9. Dysstasia (difficulty in standing)
  10. Erythema (redness of the skin)

male:

  1. Pain
  2. Rash
  3. Rash pruritic (redness with itching)

What are the common drug interactions of Leflunomide and Aubagio, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Head discomfort
  2. Idiopathic intracranial hypertension (elevated cerebrospinal fluid pressure of unknown cause)
  3. Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
  4. Chest pain
  5. Pneumonia
  6. Respiratory tract infection
  7. Blood pressure increased
  8. Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
  9. Csf pressure increased
  10. Depressed mood

60+:

  1. Diarrhoea
  2. Drug hypersensitivity
  3. Memory impairment

What are the existing conditions these people have? *

  1. Depression: 6 people, 30.00%
  2. Polycystic Ovary Disease (cysts in the ovaries that occurs when the follicle stops developing): 5 people, 25.00%
  3. Gait Disturbance: 1 person, 5.00%
  4. Diabetes: 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Leflunomide and Aubagio?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Leflunomide and Aubagio:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Leflunomide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Aubagio:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Leflunomide and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Aubagio and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on leflunomide and teriflunomide (the active ingredients of Leflunomide and Aubagio, respectively), and Leflunomide and Aubagio (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe:

© 2026 eHealthMe.com. All rights reserved. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy.