Leflunomide and Revatio drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Leflunomide (leflunomide) and Revatio (sildenafil citrate). Common drug interactions include sepsis among females and atrial tachycardia among males.

The phase IV clinical study analyzes what interactions people have when they take Leflunomide and Revatio. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Leflunomide?

Leflunomide has active ingredients of leflunomide. It is often used in rheumatoid arthritis. eHealthMe is studying from 82,105 Leflunomide users. Check the latest studies of Leflunomide.

What is Revatio?

Revatio has active ingredients of sildenafil citrate. It is often used in pulmonary hypertension. eHealthMe is studying from 44,849 Revatio users. Check the latest studies of Revatio.

On Aug, 08, 2026

32 people who take Leflunomide and Revatio together, and have interactions are studied.

Leflunomide and Revatio drug interactions.

What are the common drug interactions of Leflunomide and Revatio, by gender? *:

female:

Sepsis (a severe blood infection that can lead to organ failure and death)
Skin infection
Skin injury
Spinal column stenosis (narrowing of spinal column)
Syncope (loss of consciousness with an inability to maintain postural tone)
Tunnel vision (the loss of peripheral vision with retention of central vision)
Headache (pain in head)
Memory impairment
Peripheral swelling
Wrist fracture

male:

Atrial tachycardia (rhythm disturbance that arises in the atria)
Chest pain
Spinal compression fracture (fracture due to spinal compression on bone)
Anticonvulsant drug level increased
Balance disorder
Dizziness
Fluid overload (too much fluid in the blood)
Gait disturbance
Lung infection
Strabismus (a disorder in which the two eyes do not line up in the same direction)

What are the common drug interactions of Leflunomide and Revatio, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Multiple allergies (allergy to multiple agents)

40-49:

Anticonvulsant drug level increased
Balance disorder
Dizziness
Gait disturbance
Lung infection
Pneumonia
Strabismus (a disorder in which the two eyes do not line up in the same direction)
Vision blurred
Visual impairment
Weight decreased

50-59:

Weight increased
Wrist fracture
Dyspnoea (difficult or laboured respiration)
Syncope (loss of consciousness with an inability to maintain postural tone)
Alanine aminotransferase increased
Anaemia (lack of blood)
Aspartate aminotransferase increased
Atrial tachycardia (rhythm disturbance that arises in the atria)
Blood alkaline phosphatase increased
Chest pain

60+:

Fall
Headache (pain in head)
Dyspnoea (difficult or laboured respiration)
Blood pressure diastolic decreased
Contusion (a type of hematoma of tissue in which capillaries)
Device dislocation
Diarrhoea
Dyspepsia (indigestion)
Fractured sacrum
Hyperaemia (increase of blood flow to different tissues in the body)

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 17 people, 53.12%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 6 people, 18.75%
Pain: 6 people, 18.75%
Hypoaesthesia (reduced sense of touch or sensation): 4 people, 12.50%
Depression: 4 people, 12.50%
Fibromyalgia (a long-term condition which causes pain all over the body): 4 people, 12.50%
Gastric Disorder (disease of stomach): 4 people, 12.50%
High Blood Cholesterol: 4 people, 12.50%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 4 people, 12.50%
Irritable Bowel Syndrome: 4 people, 12.50%

* Approximation only. Some reports may have incomplete information.

Do you take Leflunomide and Revatio?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously