Leqvio and Ibu drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Leqvio (inclisiran sodium) and Ibu (ibuprofen). Common drug interactions include haematoma among females and angina pectoris among males.

The phase IV clinical study analyzes what interactions people have when they take Leqvio and Ibu. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Leqvio?

Leqvio has active ingredients of inclisiran sodium. eHealthMe is studying from 4,052 Leqvio users. Check the latest studies of Leqvio.

What is Ibu?

Ibu has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 246,531 Ibu users. Check the latest studies of Ibu.



On Aug, 04, 2026

21 people who take Leqvio and Ibu together, and have interactions are studied.

Leqvio and Ibu drug interactions.

What are the common drug interactions of Leqvio and Ibu, by gender? *:

female:

  1. Haematoma (collection of blood outside the blood vessels)
  2. Myalgia (muscle pain)
  3. Contusion (a type of hematoma of tissue in which capillaries)
  4. Haemorrhage (bleeding)
  5. Hypersensitivity
  6. Morphoea (a disorder characterized by excessive collagen deposition leading to thickening of skin)
  7. Spinal stenosis (narrowing of spinal column)
  8. Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
  9. Fibromyalgia (a long-term condition which causes pain all over the body)
  10. Induration (thickening of tissue)

male:

  1. Angina pectoris (chest pain due to ischemia of the heart muscle)
  2. Fatigue (feeling of tiredness)
  3. Retinal vein occlusion (a blockage of the small veins that carry blood away from the retina)
  4. Sensory disturbance (sense disturbance)
  5. Urinary tract infection
  6. Visual acuity reduced (reduced clearness of vision)
  7. Vertigo
  8. Arthralgia (joint pain)
  9. Dysuria (painful or difficult urination)
  10. Injection site erythema (redness at injection site)

What are the common drug interactions of Leqvio and Ibu, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Peripheral vascular disorder
  2. Retinal vein occlusion (a blockage of the small veins that carry blood away from the retina)
  3. Sensory disturbance (sense disturbance)
  4. Visual acuity reduced (reduced clearness of vision)

50-59:

  1. Angina pectoris (chest pain due to ischemia of the heart muscle)
  2. Fatigue (feeling of tiredness)
  3. Vertigo

60+:

  1. Arthralgia (joint pain)
  2. Myalgia (muscle pain)
  3. Injection site erythema (redness at injection site)
  4. Injection site pain
  5. Pain in extremity
  6. Urinary tract infection
  7. Fatigue (feeling of tiredness)
  8. Gait disturbance
  9. Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
  10. Neuropathy peripheral (surface nerve damage)

What are the existing conditions these people have? *

  1. Neuralgia (pain in one or more nerves): 15 people, 71.43%
  2. Spinal Stenosis (narrowing of spinal column): 12 people, 57.14%
  3. Hyperlipidaemia (presence of excess lipids in the blood): 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Leqvio and Ibu:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Leqvio:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Ibu:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Leqvio and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Ibu and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on inclisiran sodium and ibuprofen (the active ingredients of Leqvio and Ibu, respectively), and Leqvio and Ibu (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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