Letairis and Zosyn drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Letairis (ambrisentan) and Zosyn (piperacillin sodium; tazobactam sodium). Common drug interactions include death among females.

The phase IV clinical study analyzes what interactions people have when they take Letairis and Zosyn. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Letairis?

Letairis has active ingredients of ambrisentan. It is often used in pulmonary hypertension. eHealthMe is studying from 94,041 Letairis users. Check the latest studies of Letairis.

What is Zosyn?

Zosyn has active ingredients of piperacillin sodium; tazobactam sodium. It is often used in pneumonia. eHealthMe is studying from 10,236 Zosyn users. Check the latest studies of Zosyn.

On Jul, 18, 2026

16 people who take Letairis and Zosyn together, and have interactions are studied.

What are the common drug interactions of Letairis and Zosyn, by gender? *:

female:

Death
Nausea (feeling of having an urge to vomit)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Hypotension (abnormally low blood pressure)
Renal failure acute (rapid kidney dysfunction)
Sepsis (a severe blood infection that can lead to organ failure and death)
Septic shock (shock due to blood infection)
Bacteraemia (presence of bacteria in the blood)
Chronic kidney disease
Deafness

male:

n/a

What are the common drug interactions of Letairis and Zosyn, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Right ventricular failure (right half of the heart fails to work)

40-49:

Bacteraemia (presence of bacteria in the blood)
Decreased appetite
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Diarrhoea
Drug hypersensitivity
Gait disturbance
Headache (pain in head)
Infusion site erythema (reddening of the skin at infusion site)
Infusion site induration
Infusion site pain

50-59:

Death

60+:

Altered state of consciousness (altered state of mind)
Hypotension (abnormally low blood pressure)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Renal failure acute (rapid kidney dysfunction)
Respiratory failure (inadequate gas exchange by the respiratory system)
Septic shock (shock due to blood infection)
Chronic kidney disease
Death
Disease progression

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 12 people, 75.00%
Systemic Sclerosis (Scleroderma) (an autoimmune or connective tissue disease. it is characterized by thickening of the skin): 1 person, 6.25%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 1 person, 6.25%
Sleep Apnea Syndrome: 1 person, 6.25%
Oedema (fluid collection in tissue): 1 person, 6.25%
High Blood Cholesterol: 1 person, 6.25%
Gout (uric acid crystals building up in the body): 1 person, 6.25%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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