Letrozole and Hydrocodone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Letrozole (letrozole) and Hydrocodone (hydrocodone bitartrate; ibuprofen). Common drug interactions include weight decreased among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Letrozole and Hydrocodone. It is created by eHealthMe based on reports of 59 people who take the same drugs from the FDA, and is updated regularly.

What is Letrozole?

Letrozole has active ingredients of letrozole. It is often used in breast cancer. eHealthMe is studying from 54,125 Letrozole users. Check the latest studies of Letrozole.

What is Hydrocodone?

Hydrocodone has active ingredients of hydrocodone bitartrate; ibuprofen. eHealthMe is studying from 13,115 Hydrocodone users. Check the latest studies of Hydrocodone.

On Jul, 16, 2026

59 people who take Letrozole and Hydrocodone together, and have interactions are studied.

Letrozole and Hydrocodone drug interactions.

What are the common drug interactions of Letrozole and Hydrocodone, by gender? *:

female:

Weight decreased
Weight increased
Arthralgia (joint pain)
Neoplasm progression (growth of tumour)
Neutropenia (an abnormally low number of neutrophils)
Asthenia (weakness)
Pain
Pain in extremity
White blood cell count decreased
Alopecia (absence of hair from areas of the body)

male:

Asthenia (weakness)
Cough
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Insomnia (sleeplessness)
Muscle spasms (muscle contraction)
Rhinorrhoea (watery mucus discharge from the nose)

What are the common drug interactions of Letrozole and Hydrocodone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Cough
Maculopathy (a condition or disease of the macula, the small spot in the retina where vision is keenest)
Retinal degeneration (death of the cells of the retina)
Rhinorrhoea (watery mucus discharge from the nose)

40-49:

Fatigue (feeling of tiredness)
Back pain
Dizziness
Myelosuppression (a decrease in the production of blood cells)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Alopecia (absence of hair from areas of the body)
Arthralgia (joint pain)
Asthenia (weakness)
Breast tenderness
Cellulitis (infection under the skin)

50-59:

Haemoglobin decreased
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Hair colour changes
Hair disorder
Headache (pain in head)
Hepatic enzyme increased
Hyperhidrosis (abnormally increased sweating)
Hypersensitivity
Hypertension (high blood pressure)
Ill-defined disorder

60+:

Pyrexia (fever)
Fatigue (feeling of tiredness)
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Neutropenia (an abnormally low number of neutrophils)
Oropharyngeal pain
Pharyngeal haemorrhage (pharyngeal bleeding)
Skin plaque (red, scaly patches to appear on the skin)
Tremor (trembling or shaking movements in one or more parts of your body)
Urinary tract infection

What are the existing conditions these people have? *

Breast Cancer Female: 15 people, 25.42%
Pain: 9 people, 15.25%
Breast Cancer Metastatic: 6 people, 10.17%
Stress And Anxiety: 3 people, 5.08%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 5.08%
Multiple Myeloma (cancer of the plasma cells): 3 people, 5.08%
Depression: 3 people, 5.08%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 3 people, 5.08%
Back Pain: 3 people, 5.08%

* Approximation only. Some reports may have incomplete information.

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