Letrozole and Motrin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Letrozole (letrozole) and Motrin (ibuprofen). Common drug interactions include back pain among females and abdominal distension among males.

The phase IV clinical study analyzes what interactions people have when they take Letrozole and Motrin. It is created by eHealthMe based on reports of 74 people who take the same drugs from the FDA, and is updated regularly.

What is Letrozole?

Letrozole has active ingredients of letrozole. It is often used in breast cancer. eHealthMe is studying from 54,125 Letrozole users. Check the latest studies of Letrozole.

What is Motrin?

Motrin has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 38,332 Motrin users. Check the latest studies of Motrin.

On Jul, 13, 2026

74 people who take Letrozole and Motrin together, and have interactions are studied.

What are the common drug interactions of Letrozole and Motrin, by gender? *:

female:

Back pain
Depression
Nausea (feeling of having an urge to vomit)
Weight decreased
Bone pain
Epistaxis (bleed from the nose)
Arthralgia (joint pain)
Dyspnoea (difficult or laboured respiration)
Oropharyngeal pain
Osteoarthritis (a joint disease caused by cartilage loss in a joint)

male:

Abdominal distension
Abdominal hernia
Bone pain
Cervicitis (inflammation of the uterine cervix)
Chest pain
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Cough
Cutis laxa (connective tissue disorder in which the skin lacks elasticity and hangs in loose folds)
Death
Dehydration (dryness resulting from the removal of water)

What are the common drug interactions of Letrozole and Motrin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteopenia (a condition where bone mineral density is lower than normal)
Vomiting
Weight decreased
Anxiety
Hot flush (sudden feelings of heat)
Nausea (feeling of having an urge to vomit)
Oropharyngeal pain
Pruritus (severe itching of the skin)
Arthralgia (joint pain)

50-59:

Alopecia (absence of hair from areas of the body)
Dry skin
Fatigue (feeling of tiredness)
Malaise (a feeling of general discomfort or uneasiness)
Psychological trauma
Back pain
Emotional distress
Full blood count decreased
Hair colour changes
Hair disorder

60+:

Alopecia (absence of hair from areas of the body)
Fatigue (feeling of tiredness)
Oral pain
Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Renal tubular necrosis (death of kidney tubules)
Weight decreased
Abdominal discomfort
Anaemia (lack of blood)
Appetite disorder (abnormal eating habits)

What are the existing conditions these people have? *

Breast Cancer Female: 14 people, 18.92%
Breast Cancer Metastatic: 12 people, 16.22%
Stress And Anxiety: 6 people, 8.11%
Back Pain: 5 people, 6.76%
Osteoporosis (bones weak and more likely to break): 4 people, 5.41%
Fever: 4 people, 5.41%
Bone Loss: 4 people, 5.41%

* Approximation only. Some reports may have incomplete information.

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