Letrozole and Trimethoprim drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Letrozole (letrozole) and Trimethoprim (trimethoprim). Common drug interactions include diarrhoea among females.

The phase IV clinical study analyzes what interactions people have when they take Letrozole and Trimethoprim. It is created by eHealthMe based on reports of 89 people who take the same drugs from the FDA, and is updated regularly.

What is Letrozole?

Letrozole has active ingredients of letrozole. It is often used in breast cancer. eHealthMe is studying from 54,125 Letrozole users. Check the latest studies of Letrozole.

What is Trimethoprim?

Trimethoprim has active ingredients of trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 8,213 Trimethoprim users. Check the latest studies of Trimethoprim.

On Jul, 08, 2026

89 people who take Letrozole and Trimethoprim together, and have interactions are studied.

Letrozole and Trimethoprim drug interactions.

What are the common drug interactions of Letrozole and Trimethoprim, by gender? *:

female:

Diarrhoea
Neutropenic sepsis (whole body infection is caused by a condition in which the number of white blood cells (called neutrophils) in the blood is low. neutrophils help the body to fight infection)
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Rash pruritic (redness with itching)
Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream)
Death
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Asthenia (weakness)
Cellulitis (infection under the skin)

male:

n/a

What are the common drug interactions of Letrozole and Trimethoprim, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Hydronephrosis (water inside the kidney)
Insomnia (sleeplessness)
Neuropathy peripheral (surface nerve damage)
Conjunctivitis (pink eye)
Nausea (feeling of having an urge to vomit)
Oral candidiasis (fungal infection of mouth)
Rectal haemorrhage (bleeding from anus)
Vulvovaginal candidiasis (vulvovaginal infection by fungi)
Abnormal sensation in eye
Asthenia (weakness)

50-59:

Cellulitis (infection under the skin)
Constipation
Diarrhoea
Escherichia infection (bacterial infection by escherichia coli)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Klebsiella infection
Lower respiratory tract infection
Pneumonia
Pyrexia (fever)
Sepsis (a severe blood infection that can lead to organ failure and death)

60+:

Diarrhoea
Neutropenic sepsis (whole body infection is caused by a condition in which the number of white blood cells (called neutrophils) in the blood is low. neutrophils help the body to fight infection)
Rash pruritic (redness with itching)
Rectal haemorrhage (bleeding from anus)
Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream)
Death
Headache (pain in head)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Pain in extremity
Swelling face

What are the existing conditions these people have? *

Breast Cancer Metastatic: 62 people, 69.66%
High Blood Pressure: 31 people, 34.83%
Cellulitis (infection under the skin): 29 people, 32.58%
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood): 26 people, 29.21%
Hypercalcaemia Of Malignancy (elevated calcium (ca+) level in the blood with cancer): 25 people, 28.09%
Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood): 25 people, 28.09%
Back Pain: 25 people, 28.09%
Blood Phosphorus Decreased: 25 people, 28.09%
Blood Potassium Decreased: 25 people, 28.09%
Gastrointestinal Motility Disorder (abnormal intestinal contractions): 25 people, 28.09%

* Approximation only. Some reports may have incomplete information.

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