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Letrozole and Unisom drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Letrozole (letrozole) and Unisom (doxylamine succinate). Common drug interactions include fatigue among females.

The phase IV clinical study analyzes what interactions people have when they take Letrozole and Unisom. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Letrozole?

Letrozole has active ingredients of letrozole. It is often used in breast cancer. eHealthMe is studying from 54,125 Letrozole users. Check the latest studies of Letrozole.

What is Unisom?

Unisom has active ingredients of doxylamine succinate. It is often used in insomnia. eHealthMe is studying from 3,875 Unisom users. Check the latest studies of Unisom.

On Aug, 04, 2026

17 people who take Letrozole and Unisom together, and have interactions are studied.

Letrozole and Unisom drug interactions.

What are the common drug interactions of Letrozole and Unisom, by gender? *:

female:

  1. Fatigue (feeling of tiredness)
  2. Headache (pain in head)
  3. Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
  4. Chest pain
  5. Conjunctivitis (pink eye)
  6. Decreased interest
  7. Depression
  8. Dyspepsia (indigestion)
  9. Dyspnoea (difficult or laboured respiration)
  10. Femur fracture

male:

n/a

What are the common drug interactions of Letrozole and Unisom, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Anaemia (lack of blood)
  2. Anxiety
  3. Back pain
  4. Bone disorder
  5. Bone pain
  6. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  7. Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
  8. Chest pain
  9. Conjunctivitis (pink eye)
  10. Decreased interest

50-59:

  1. Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
  2. White blood cell count decreased

60+:

  1. Fatigue (feeling of tiredness)
  2. Abdominal pain upper
  3. Hunger
  4. Osteonecrosis of jaw (death of bone of jaw)
  5. Tumour marker increased
  6. Alopecia (absence of hair from areas of the body)
  7. Headache (pain in head)
  8. Irritability
  9. Nausea (feeling of having an urge to vomit)
  10. Rhinorrhoea (watery mucus discharge from the nose)

What are the existing conditions these people have? *

  1. Breast Cancer Female: 7 people, 41.18%
  2. Multiple Myeloma (cancer of the plasma cells): 2 people, 11.76%
  3. Nervousness: 1 person, 5.88%
  4. Discomfort: 1 person, 5.88%
  5. Abnormal Behavior: 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Letrozole and Unisom?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Letrozole and Unisom:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Letrozole:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Unisom:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Letrozole and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Unisom and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on letrozole and doxylamine succinate (the active ingredients of Letrozole and Unisom, respectively), and Letrozole and Unisom (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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