Levemir and Lotrel drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Levemir (insulin detemir recombinant) and Lotrel (amlodipine besylate; benazepril hydrochloride). Common drug interactions include headache among females and balance disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Levemir and Lotrel. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Levemir?

Levemir has active ingredients of insulin detemir recombinant. It is often used in diabetes. eHealthMe is studying from 13,850 Levemir users. Check the latest studies of Levemir.

What is Lotrel?

Lotrel has active ingredients of amlodipine besylate; benazepril hydrochloride. It is often used in high blood pressure. eHealthMe is studying from 13,571 Lotrel users. Check the latest studies of Lotrel.

On Jul, 12, 2026

30 people who take Levemir and Lotrel together, and have interactions are studied.

What are the common drug interactions of Levemir and Lotrel, by gender? *:

female:

Headache (pain in head)
Hyperhidrosis (abnormally increased sweating)
Increased appetite
Petechiae (a small red or purple spot caused by bleeding into the skin)
Therapeutic response decreased (less preventive response)
Thrombocytosis
Tremor (trembling or shaking movements in one or more parts of your body)
Weight decreased
Amnestic disorder (group of disorders that involve loss of memories previously established, loss of the ability to create new memories)
Blood thyroid stimulating hormone increased

male:

Balance disorder
Fall
Vascular graft occlusion
Weight decreased
Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Asthma
Back pain
Blood glucose decreased
Blood pressure diastolic increased

What are the common drug interactions of Levemir and Lotrel, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal discomfort
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Bile duct stone
Chest discomfort
Nausea (feeling of having an urge to vomit)
Pancreatitis (inflammation of pancreas)
Renal injury (kidney injury)
Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)
Urticaria (rash of round, red welts on the skin that itch intensely)

30-39:

n/a

40-49:

Electrocardiogram qt prolonged
Erectile dysfunction
Escherichia test positive
Faeces discoloured
Fall
Gastritis (inflammation of stomach)
Gastroenteritis (inflammation of stomach and intestine)
Headache (pain in head)
Hypoaesthesia (reduced sense of touch or sensation)
Influenza like illness

50-59:

Abdominal discomfort
Bile duct stone
Blood glucose decreased
Blood glucose increased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Nausea (feeling of having an urge to vomit)
Pancreatitis (inflammation of pancreas)
Renal injury (kidney injury)
Weight decreased
Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)

60+:

Contusion (a type of hematoma of tissue in which capillaries)
Epistaxis (bleed from the nose)
Muscle disorder (muscle disease)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Renal failure chronic (long lasting kidney dysfunction)
Vascular graft occlusion
Abdominal pain upper
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Diabetes mellitus inadequate control
Abnormal weight gain

What are the existing conditions these people have? *

High Blood Cholesterol: 4 people, 13.33%
Type 2 Diabetes: 3 people, 10.00%
Idiopathic Thrombocytopenic Purpura (bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting): 3 people, 10.00%
Depression: 3 people, 10.00%
Type 1 Diabetes: 2 people, 6.67%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 2 people, 6.67%
Pain: 2 people, 6.67%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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