Levitra and Depakote drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Levitra (vardenafil hydrochloride) and Depakote (divalproex sodium). Common drug interactions include pain among males.

The phase IV clinical study analyzes what interactions people have when they take Levitra and Depakote. It is created by eHealthMe based on reports of 42 people who take the same drugs from the FDA, and is updated regularly.

What is Levitra?

Levitra has active ingredients of vardenafil hydrochloride. It is often used in erection problems. eHealthMe is studying from 10,392 Levitra users. Check the latest studies of Levitra.

What is Depakote?

Depakote has active ingredients of divalproex sodium. It is often used in bipolar disorder. eHealthMe is studying from 55,581 Depakote users. Check the latest studies of Depakote.

On Jul, 17, 2026

42 people who take Levitra and Depakote together, and have interactions are studied.

What are the common drug interactions of Levitra and Depakote, by gender? *:

female:

n/a

male:

Pain
Dysarthria (speech disorder)
Depression
Arthralgia (joint pain)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Somnolence (a state of near-sleep, a strong desire for sleep)
Cerebral ischaemia (insufficient blood flow to the brain to meet metabolic demand)
Diplopia (double vision)
Encephalitis (inflammation of the brain)
Headache (pain in head)

What are the common drug interactions of Levitra and Depakote, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Type 2 diabetes mellitus
Arthralgia (joint pain)
Autonomic neuropathy (malfunction of the autonomic nervous system (ans))
Blood glucose increased
Blood sodium decreased
Cardiac disorder
Chest pain
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Diabetes mellitus inadequate control
Diabetic autonomic neuropathy (diabetes with nerve disorder, painful muscle wasting and weakness)

40-49:

Diabetic nephropathy (diabetic kidney disease)
Dissociative disorder
Emotional disorder
Essential hypertension (primary hypertension)
Exostosis (formation of new bone on the surface of a bone)
Gait disturbance
Granuloma (a small area of inflammation due to tissue injury)
Haemorrhage (bleeding)
Hydrocephalus (water on the brain)
Hypotension (abnormally low blood pressure)

50-59:

Chronic kidney disease
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Diarrhoea
Diverticulum intestinal (a pouch that is attached to the first part of the small intestine)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Haemoglobin decreased
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Hyperlipidaemia (presence of excess lipids in the blood)

60+:

Ejaculation failure
Arthralgia (joint pain)
Chronic myeloid leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood)
Interstitial lung disease
Pneumonia
Rash
Vasculitis (inflammation of a blood vessel or blood vessels)

What are the existing conditions these people have? *

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 6 people, 14.29%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 11.90%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 4 people, 9.52%
Sarcoidosis (an inflammatory disease that affects multiple organs in the body, but mostly the lungs and lymph glands): 4 people, 9.52%
Myoclonus (a brief, involuntary twitching of a muscle or a group of muscles): 4 people, 9.52%
Juvenile Myoclonic Epilepsy (childhood epilepsy occurring early in morning affecting 12 to 18 years): 4 people, 9.52%
Ill-Defined Disorder: 4 people, 9.52%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 9.52%
Pain: 3 people, 7.14%
Muscle Spasms (muscle contraction): 3 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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