Levonorgestrel and Provigil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Levonorgestrel (levonorgestrel) and Provigil (modafinil). Common drug interactions include cough among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Levonorgestrel and Provigil. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Levonorgestrel?

Levonorgestrel has active ingredients of levonorgestrel. It is often used in birth control. eHealthMe is studying from 4,186 Levonorgestrel users. Check the latest studies of Levonorgestrel.

What is Provigil?

Provigil has active ingredients of modafinil. It is often used in narcolepsy. eHealthMe is studying from 25,230 Provigil users. Check the latest studies of Provigil.



On Jul, 17, 2026

15 people who take Levonorgestrel and Provigil together, and have interactions are studied.

Levonorgestrel and Provigil drug interactions.

What are the common drug interactions of Levonorgestrel and Provigil, by gender? *:

female:

  1. Cough
  2. Dysgeusia (disorder of the sense of taste)
  3. Lupus-like syndrome (a disease symptom matches with lupus an immune disease)
  4. Rash erythematous (redness of the skin)
  5. Respiratory tract infection
  6. Abdominal discomfort
  7. Abdominal pain
  8. Arthritis (form of joint disorder that involves inflammation of one or more joints)
  9. Asthma
  10. Blood pressure increased

male:

  1. Anxiety
  2. Aphasia (damage to the parts of the brain that control language)
  3. Anaemia (lack of blood)
  4. Anger
  5. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  6. Aortic arteriosclerosis (hardening of the aortic arteries)
  7. Asthenia (weakness)
  8. Atrophy (wasting away of a part of the body)
  9. Back pain
  10. Bone disorder

What are the common drug interactions of Levonorgestrel and Provigil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Rash erythematous (redness of the skin)
  2. Abdominal discomfort
  3. Asthma
  4. Blood pressure increased
  5. Cough
  6. Dizziness
  7. Drug ineffective
  8. Fall
  9. Feeling drunk
  10. Hospitalisation

40-49:

n/a

50-59:

n/a

60+:

  1. Anxiety
  2. Aphasia (damage to the parts of the brain that control language)
  3. Anaemia (lack of blood)
  4. Anger
  5. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  6. Aortic arteriosclerosis (hardening of the aortic arteries)
  7. Asthenia (weakness)
  8. Atrophy (wasting away of a part of the body)
  9. Back pain
  10. Bone disorder

What are the existing conditions these people have? *

  1. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 10 people, 66.67%
  2. Drowsiness: 3 people, 20.00%
  3. Asthma: 3 people, 20.00%
  4. Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 1 person, 6.67%
  5. Raynaud's Phenomenon (discoloration of the fingers, toes, and occasionally other areas): 1 person, 6.67%
  6. Osteopenia (a condition where bone mineral density is lower than normal): 1 person, 6.67%
  7. Insomnia (sleeplessness): 1 person, 6.67%
  8. Ill-Defined Disorder: 1 person, 6.67%
  9. High Blood Pressure: 1 person, 6.67%
  10. Fatigue (feeling of tiredness): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Levonorgestrel and Provigil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Levonorgestrel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Provigil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Levonorgestrel and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Provigil and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on levonorgestrel and modafinil (the active ingredients of Levonorgestrel and Provigil, respectively), and Levonorgestrel and Provigil (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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