Levothroid and Actonel drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Levothroid (levothyroxine sodium) and Actonel (risedronate sodium). Common drug interactions include balance disorder among females and pancreas infection among males.

The phase IV clinical study analyzes what interactions people have when they take Levothroid and Actonel. It is created by eHealthMe based on reports of 69 people who take the same drugs from the FDA, and is updated regularly.

What is Levothroid?

Levothroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 8,974 Levothroid users. Check the latest studies of Levothroid.

What is Actonel?

Actonel has active ingredients of risedronate sodium. It is often used in osteoporosis. eHealthMe is studying from 29,369 Actonel users. Check the latest studies of Actonel.

On Aug, 11, 2026

69 people who take Levothroid and Actonel together, and have interactions are studied.

Levothroid and Actonel drug interactions.

What are the common drug interactions of Levothroid and Actonel, by gender? *:

female:

Balance disorder
Blood glucose increased
Blood urea increased
Bursa injury
Cardioactive drug level increased
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Complex regional pain syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet))
Cough
Dysgeusia (disorder of the sense of taste)
Fatigue (feeling of tiredness)

male:

Pancreas infection
Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
Hypertension (high blood pressure)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Road traffic accident
Anxiety
Arthropathy
Asthma
Blood cholesterol increased
Dehydration (dryness resulting from the removal of water)

What are the common drug interactions of Levothroid and Actonel, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Adverse event
Anaemia (lack of blood)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Cytomegalovirus chorioretinitis (infection of choroid and retina of the eye from virus)
Cytomegalovirus oesophagitis (oesophagus infection with cytomegalo virus)
Fall
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Jaw disorder (jaw disease)
Lymphoproliferative disorder (a medical condition in which the immune system makes too many white blood cells)

50-59:

Burning sensation
Candidiasis (candidiasis or thrush is a fungal infection)
Coma (state of unconsciousness lasting more than six hours)
Contusion (a type of hematoma of tissue in which capillaries)
Depression
Drug ineffective
Emotional distress
Fall
Fracture malunion (fracture has healed, but that it has healed in less than an optimal position)
Gastrointestinal necrosis (destruction of gastrointestinal organ)

60+:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Decreased appetite
Headache (pain in head)
Impaired healing
Nausea (feeling of having an urge to vomit)
Oedema peripheral (superficial swelling)
Chest pain
Haematoma (collection of blood outside the blood vessels)
Rash
Swelling

What are the existing conditions these people have? *

Pain: 8 people, 11.59%
Stress And Anxiety: 7 people, 10.14%
High Blood Pressure: 7 people, 10.14%
Depression: 7 people, 10.14%
Insomnia (sleeplessness): 6 people, 8.70%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 5 people, 7.25%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 4 people, 5.80%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 5.80%
Osteopenia (a condition where bone mineral density is lower than normal): 4 people, 5.80%

* Approximation only. Some reports may have incomplete information.

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