Levothroid and Lortab drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Levothroid (levothyroxine sodium) and Lortab (acetaminophen; hydrocodone bitartrate). Common drug interactions include neuralgia among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Levothroid and Lortab. It is created by eHealthMe based on reports of 74 people who take the same drugs from the FDA, and is updated regularly.

What is Levothroid?

Levothroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 8,974 Levothroid users. Check the latest studies of Levothroid.

What is Lortab?

Lortab has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 31,285 Lortab users. Check the latest studies of Lortab.

On Jul, 22, 2026

74 people who take Levothroid and Lortab together, and have interactions are studied.

Levothroid and Lortab drug interactions.

What are the common drug interactions of Levothroid and Lortab, by gender? *:

female:

Neuralgia (pain in one or more nerves)
Oxygen saturation decreased
Urinary tract infection
Abdominal pain upper
Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)
Blood potassium decreased
Chest pain

male:

Diarrhoea
Adverse event
Agitation (state of anxiety or nervous excitement)
Anaemia postoperative
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Blood pressure increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac failure congestive

What are the common drug interactions of Levothroid and Lortab, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Delusion (a false belief or opinion)
Hallucinations, mixed (sensations that appear real but are created by your mind -mixed)
Psychotic disorder
Nightmare (unpleasant dream)
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Abdominal pain
Abdominal tenderness
Abnormal behaviour
Depression
Gastric polyps (abnormal growth of stomach tissue projecting from a mucous membrane)

40-49:

Dehydration (dryness resulting from the removal of water)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Renal failure (kidney dysfunction)
Respiratory disorder (respiratory disease)
Starvation (a severe deficiency in caloric energy, nutrient, and vitamin intake)
Urinary retention (the inability to completely or partially empty the bladder)
Weight decreased

50-59:

Cardiac failure congestive
Headache (pain in head)
Atelectasis (partial or complete collapse of the lung)
Dizziness
Hypertension (high blood pressure)
Neuralgia (pain in one or more nerves)
Oxygen saturation decreased
Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
Dyspnoea (difficult or laboured respiration)
Hypotension (abnormally low blood pressure)

60+:

Weight decreased
Pyrexia (fever)
Speech disorder
Spinal cord abscess (pus in spinal cord)
Blood calcium decreased
Blood magnesium decreased
Heart rate increased
Hypotension (abnormally low blood pressure)
Streptococcal sepsis (whole body inflammation by streptococcal)
Vitamin d decreased

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 9.46%
Multiple Myeloma (cancer of the plasma cells): 7 people, 9.46%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 9.46%
Nausea (feeling of having an urge to vomit): 6 people, 8.11%
Joint Pain: 6 people, 8.11%
Hyperlipidaemia (presence of excess lipids in the blood): 6 people, 8.11%
Blood Pressure Diastolic Increased: 6 people, 8.11%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 6 people, 8.11%
Immunodeficiency: 5 people, 6.76%
High Blood Pressure: 5 people, 6.76%

* Approximation only. Some reports may have incomplete information.

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