Levothroid and Melatonin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Levothroid (levothyroxine sodium) and Melatonin (melatonin). Common drug interactions include diastolic dysfunction among females and dry mouth among males.

The phase IV clinical study analyzes what interactions people have when they take Levothroid and Melatonin. It is created by eHealthMe based on reports of 49 people who take the same drugs from the FDA, and is updated regularly.

What is Levothroid?

Levothroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 8,974 Levothroid users. Check the latest studies of Levothroid.

What is Melatonin?

Melatonin has active ingredients of melatonin. It is often used in insomnia. eHealthMe is studying from 56,212 Melatonin users. Check the latest studies of Melatonin.

On Jul, 05, 2026

49 people who take Levothroid and Melatonin together, and have interactions are studied.

Levothroid and Melatonin drug interactions.

What are the common drug interactions of Levothroid and Melatonin, by gender? *:

female:

Diastolic dysfunction
Disease recurrence
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Dry eye (lack of adequate tears)
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Eye irritation
Eye pruritus (eye itching)
Fatigue (feeling of tiredness)
Femur fracture

male:

Dry mouth
Aphasia (damage to the parts of the brain that control language)
Arthralgia (joint pain)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Blood pressure diastolic decreased
Chronic hepatic failure (long lasting liver failure)
Confusional state
Contusion (a type of hematoma of tissue in which capillaries)
Death
Ear pain

What are the common drug interactions of Levothroid and Melatonin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Injury
Pain

30-39:

n/a

40-49:

Anaemia (lack of blood)
Asthenia (weakness)
Balance disorder
Blindness unilateral
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Gait disturbance
Hysterectomy
Muscular weakness (muscle weakness)
Nausea (feeling of having an urge to vomit)
Uterine leiomyoma (uterine benign tumour derived from smooth muscle)

50-59:

Pneumonia
Nausea (feeling of having an urge to vomit)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Hypoaesthesia (reduced sense of touch or sensation)
Malaise (a feeling of general discomfort or uneasiness)
Abdominal pain
Arthralgia (joint pain)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Blood creatine phosphokinase increased

60+:

Back pain
Nausea (feeling of having an urge to vomit)
Pain
Pneumonia
Pleural effusion (water on the lungs)
Vomiting
Abdominal distension
Abdominal pain
Abdominal pain upper
Acute myocardial infarction (acute heart attack)

What are the existing conditions these people have? *

Pain: 7 people, 14.29%
Nausea (feeling of having an urge to vomit): 5 people, 10.20%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 10.20%
High Blood Pressure: 4 people, 8.16%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 8.16%
Type 2 Diabetes: 3 people, 6.12%
Thyroid Cancer: 3 people, 6.12%
Stress And Anxiety: 3 people, 6.12%
Sleep Disorder: 3 people, 6.12%
Neuropathy Peripheral (surface nerve damage): 3 people, 6.12%

* Approximation only. Some reports may have incomplete information.

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