Levothroid and Metolazone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Levothroid (levothyroxine sodium) and Metolazone (metolazone). Common drug interactions include aortic stenosis among females and dizziness among males.

The phase IV clinical study analyzes what interactions people have when they take Levothroid and Metolazone. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Levothroid?

Levothroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 8,974 Levothroid users. Check the latest studies of Levothroid.

What is Metolazone?

Metolazone has active ingredients of metolazone. It is often used in swelling. eHealthMe is studying from 13,411 Metolazone users. Check the latest studies of Metolazone.

On Jul, 11, 2026

23 people who take Levothroid and Metolazone together, and have interactions are studied.

Levothroid and Metolazone drug interactions.

What are the common drug interactions of Levothroid and Metolazone, by gender? *:

female:

Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)
Cellulitis (infection under the skin)
Peripheral swelling
Pneumonia
Renal failure (kidney dysfunction)
Cough
Dyspnoea (difficult or laboured respiration)
Medical device complication
Nausea (feeling of having an urge to vomit)
Presyncope

male:

Dizziness
Chronic kidney disease
Blood potassium decreased
Confusional state
Diarrhoea
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea (difficult or laboured respiration)
Electrocardiogram st segment depression
Electrocardiogram t wave inversion
Flatulence (flatus expelled through the anus)

What are the common drug interactions of Levothroid and Metolazone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Chronic kidney disease
Renal failure (kidney dysfunction)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Cough
Fatigue (feeling of tiredness)
Gait disturbance

60+:

Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)
Cellulitis (infection under the skin)
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Medical device complication
Presyncope
Pulmonary hypertension (increase in blood pressure in the lung artery)
Abdominal pain lower
Acute prerenal failure (prerenal acute renal failure (arf) occurs when a sudden reduction in blood flow to the kidney)
Blood albumin decreased

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 7 people, 30.43%
Multiple Myeloma (cancer of the plasma cells): 4 people, 17.39%
Pain: 3 people, 13.04%
High Blood Pressure: 3 people, 13.04%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 13.04%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 2 people, 8.70%
Nausea (feeling of having an urge to vomit): 2 people, 8.70%
Muscle Spasms (muscle contraction): 2 people, 8.70%
Hyperuricaemia (level of uric acid in the blood that is abnormally high): 2 people, 8.70%
Gastric Ph Decreased: 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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