Levothroid and Naprosyn drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Levothroid (levothyroxine sodium) and Naprosyn (naproxen). Common drug interactions include wrist fracture among females and arthralgia among males.

The phase IV clinical study analyzes what interactions people have when they take Levothroid and Naprosyn. It is created by eHealthMe based on reports of 73 people who take the same drugs from the FDA, and is updated regularly.

What is Levothroid?

Levothroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 8,974 Levothroid users. Check the latest studies of Levothroid.

What is Naprosyn?

Naprosyn has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 16,738 Naprosyn users. Check the latest studies of Naprosyn.

On Jul, 16, 2026

73 people who take Levothroid and Naprosyn together, and have interactions are studied.

Levothroid and Naprosyn drug interactions.

What are the common drug interactions of Levothroid and Naprosyn, by gender? *:

female:

Wrist fracture
Bone density decreased
Death
Malignant neoplasm progression (cancer tumour came back)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Osteonecrosis of jaw (death of bone of jaw)
Spinal decompression (relief of pressure on one or many pinched nerves (neural impingement) of the spinal column)
Surgery
Tooth extraction
Diarrhoea

male:

Arthralgia (joint pain)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Blood prolactin increased
Blood testosterone decreased
Blood testosterone free decreased
Blood testosterone free increased
Blood testosterone increased
Blood thyroid stimulating hormone decreased
Bronchiolitis (inflammation of the membranes lining the bronchioles in lungs)
Carbon dioxide increased

What are the common drug interactions of Levothroid and Naprosyn, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal pain
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Collagen disorder (infection and weakness of collagen)
Depression
Diarrhoea
Difficulty in micturition (difficulty to urinate)
Drug dependence
Drug ineffective
Epistaxis (bleed from the nose)
Fatigue (feeling of tiredness)

30-39:

Arthralgia (joint pain)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Pancreatic mass
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Diarrhoea
Dizziness
Insomnia (sleeplessness)
Nausea (feeling of having an urge to vomit)
Night sweats (sweating in night)
Peripheral coldness

40-49:

Fatigue (feeling of tiredness)
Pyrexia (fever)
Arthropathy
Blood pressure increased
Drug intolerance (drug sensitivity)
General symptom
Infection
Injection site reaction
Pneumonia
Adenoma benign (non-cancerous tumour -secreting)

50-59:

Anaemia (lack of blood)
Arthralgia (joint pain)
Bone disorder
Bone erosion
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Excessive granulation tissue (excessive collagen-rich tissue which forms at the site of an injury)
Femoral neck fracture (neck of femur bone fracture)
Folliculitis (infection of hair root)
Gingival bleeding (bleeding gums)

60+:

Chest pain
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Flatulence (flatus expelled through the anus)
Gait disturbance
Headache (pain in head)
Herpes zoster
Hypertension (high blood pressure)
Loose stools

What are the existing conditions these people have? *

Depression: 14 people, 19.18%
Muscle Spasms (muscle contraction): 11 people, 15.07%
Breast Cancer: 11 people, 15.07%
Metastases To Bone (cancer spreads to bone): 10 people, 13.70%
Breast Cancer Metastatic: 10 people, 13.70%
Nausea (feeling of having an urge to vomit): 5 people, 6.85%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 6.85%
High Blood Cholesterol: 5 people, 6.85%
High Blood Pressure: 4 people, 5.48%
Cough: 4 people, 5.48%

* Approximation only. Some reports may have incomplete information.

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