Levothroid and Provigil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Levothroid (levothyroxine sodium) and Provigil (modafinil). Common drug interactions include saliva altered among females and pain among males.

The phase IV clinical study analyzes what interactions people have when they take Levothroid and Provigil. It is created by eHealthMe based on reports of 74 people who take the same drugs from the FDA, and is updated regularly.

What is Levothroid?

Levothroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 8,974 Levothroid users. Check the latest studies of Levothroid.

What is Provigil?

Provigil has active ingredients of modafinil. It is often used in narcolepsy. eHealthMe is studying from 25,230 Provigil users. Check the latest studies of Provigil.

On Jul, 13, 2026

74 people who take Levothroid and Provigil together, and have interactions are studied.

Levothroid and Provigil drug interactions.

What are the common drug interactions of Levothroid and Provigil, by gender? *:

female:

Saliva altered (changes in saliva composition)
Scoliosis (a medical condition in which a person's spine is curved from side to side)
Sensory disturbance (sense disturbance)
Strabismus (a disorder in which the two eyes do not line up in the same direction)
Suicide attempt
White blood cell count increased
Abdominal pain upper
Asthenia (weakness)
Coagulopathy (blood's ability to clot is impaired)
Drug ineffective

male:

Pain
Arthralgia (joint pain)
Limb injury
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Neck injury
Neck pain
Neuropathy peripheral (surface nerve damage)
Radiculopathy (a set of conditions in which one or more nerves is affected and does not work properly)
Road traffic accident
Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)

What are the common drug interactions of Levothroid and Provigil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Abnormal behaviour
Anxiety
Bruxism (habitual grinding of the teeth, typically during sleep)
Dermatillomania (skin picking disorders)
Disturbance in attention
Ear infection
Hypotonia (low muscle tone)
Increased appetite
Nail picking
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)

10-19:

Abnormal behaviour
Aggression
Coma (state of unconsciousness lasting more than six hours)
Concussion (short loss of normal brain function in response to a head injury)
Dysarthria (speech disorder)
Gait disturbance
Loss of consciousness
Pain
Personality change
Suicide attempt

20-29:

n/a

30-39:

Coagulopathy (blood's ability to clot is impaired)
Human papilloma virus test positive
Procedural complication
Delusion (a false belief or opinion)
Hallucinations, mixed (sensations that appear real but are created by your mind -mixed)
Lymphocyte count increased
Monocyte count increased
Neutrophil count increased (excess than normal number of neutrophil a type of blood cell)
Psychotic disorder
Red blood cell count decreased

40-49:

Constipation
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Enuresis (repeated inability to control urination)
Haematochezia (passage of stools containing blood)
Hepatic steatosis (fatty liver disease)
Hypotension (abnormally low blood pressure)
Infection
Insomnia (sleeplessness)
Intracranial aneurysm (bulging, weak area in the wall of a cranial artery)
Nasopharyngitis (inflammation of the nasopharynx)

50-59:

Arthralgia (joint pain)
Back injury
Back pain
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Cartilage injury
Drug dependence
Humerus fracture (injury to the upper arm bone)
Joint effusion (presence of extra fluid in joint covering)
Ligament sprain (ligament stretched)
Limb injury

60+:

Fall
Lymphopenia (an abnormally low level of lymphocytes in the blood)
Tongue oedema (swelling of tongue)
Vision blurred
Weight increased
Abnormal dreams
Apnoea (suspension of external breathing)
Difficulty in walking
Migraine (headache)
Nasopharyngitis (inflammation of the nasopharynx)

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 12 people, 16.22%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 10 people, 13.51%
Drowsiness: 8 people, 10.81%
Depression: 6 people, 8.11%
Bipolar Disorder (mood disorder): 6 people, 8.11%
Gait Disturbance: 5 people, 6.76%

* Approximation only. Some reports may have incomplete information.

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