Levothroid and Revatio drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Levothroid (levothyroxine sodium) and Revatio (sildenafil citrate). Common drug interactions include cognitive disorder among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Levothroid and Revatio. It is created by eHealthMe based on reports of 84 people who take the same drugs from the FDA, and is updated regularly.

What is Levothroid?

Levothroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 8,974 Levothroid users. Check the latest studies of Levothroid.

What is Revatio?

Revatio has active ingredients of sildenafil citrate. It is often used in pulmonary hypertension. eHealthMe is studying from 44,849 Revatio users. Check the latest studies of Revatio.

On Jul, 12, 2026

84 people who take Levothroid and Revatio together, and have interactions are studied.

Levothroid and Revatio drug interactions.

What are the common drug interactions of Levothroid and Revatio, by gender? *:

female:

Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Contusion (a type of hematoma of tissue in which capillaries)
Cough
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Dyspepsia (indigestion)
Dysstasia (difficulty in standing)
Exercise tolerance decreased
Extranodal marginal zone b-cell lymphoma (malt type) (cancer originating from b cells in the marginal zone of the malt)
Face oedema (swelling of face)
Failure to thrive (inadequate weight gain and physical growth in children)

male:

Asthenia (weakness)
Productive cough
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Death
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
General physical health deterioration (weak health status)
Pulmonary embolism (blockage of the main artery of the lung)
Cardiac failure
Epistaxis (bleed from the nose)
Fall

What are the common drug interactions of Levothroid and Revatio, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Failure to thrive (inadequate weight gain and physical growth in children)

10-19:

n/a

20-29:

Haemorrhage (bleeding)
Syphilis (sexually transmitted , chronic bacterial disease caused by the spirochete treponema pallidum)

30-39:

Menstruation delayed (late menstruation cycle)

40-49:

Influenza
Malaise (a feeling of general discomfort or uneasiness)
Nasopharyngitis (inflammation of the nasopharynx)
Cardiac failure congestive
Death
Oedema peripheral (superficial swelling)
Swelling

50-59:

Constipation
Death
Lymphopenia (an abnormally low level of lymphocytes in the blood)
White blood cell count decreased
Asthenia (weakness)
Chills (felling of cold)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Influenza
Myalgia (muscle pain)
Nausea (feeling of having an urge to vomit)

60+:

Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Dry mouth
Furuncle (infection of the hair follicle)
Headache (pain in head)
Pyrexia (fever)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Fall
Respiratory tract infection
Chills (felling of cold)

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 37 people, 44.05%
Pain: 9 people, 10.71%
Diarrhea: 5 people, 5.95%
Connective Tissue Disorder (any disease that has the connective tissues of the body): 5 people, 5.95%

* Approximation only. Some reports may have incomplete information.

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