Levothroid and Savella drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Levothroid (levothyroxine sodium) and Savella (milnacipran hydrochloride). Common drug interactions include abdominal pain upper among females.

The phase IV clinical study analyzes what interactions people have when they take Levothroid and Savella. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Levothroid?

Levothroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 8,974 Levothroid users. Check the latest studies of Levothroid.

What is Savella?

Savella has active ingredients of milnacipran hydrochloride. It is often used in fibromyalgia. eHealthMe is studying from 7,529 Savella users. Check the latest studies of Savella.

On Jul, 05, 2026

22 people who take Levothroid and Savella together, and have interactions are studied.

Levothroid and Savella drug interactions.

What are the common drug interactions of Levothroid and Savella, by gender? *:

female:

Abdominal pain upper
Delusion (a false belief or opinion)
Leukocytosis (increased white blood cells)
Malaise (a feeling of general discomfort or uneasiness)
Metabolic encephalopathy (disorder or disease of the brain due to the body's disability to use energy)
Nightmare (unpleasant dream)
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Polycythaemia (proportion of blood volume that is occupied by red blood cells increases)
Rash
Rosacea (a skin condition that causes facial redness)

male:

n/a

What are the common drug interactions of Levothroid and Savella, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Delusion (a false belief or opinion)
Hallucinations, mixed (sensations that appear real but are created by your mind -mixed)
Psychotic disorder
Nightmare (unpleasant dream)
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Abdominal pain upper
Intervertebral disc protrusion (spinal disc protrusion)
Post-traumatic stress disorder

40-49:

n/a

50-59:

n/a

60+:

Headache (pain in head)
Fall
Ear injury
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
Eye disorder
Gait disturbance
Head injury
Leukocytosis (increased white blood cells)
Lung disorder (lung disease)
Macular degeneration (painless eye condition that leads to the gradual loss of central vision)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 31.82%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 18.18%
Drowsiness: 3 people, 13.64%
Urinary Tract Infection: 2 people, 9.09%
Thyroid Diseases: 2 people, 9.09%
Oedema (fluid collection in tissue): 2 people, 9.09%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 9.09%
Migraine (headache): 2 people, 9.09%
Depression: 2 people, 9.09%
Constipation: 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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