Levothroid and Septra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Levothroid (levothyroxine sodium) and Septra (sulfamethoxazole; trimethoprim). Common drug interactions include abscess among females and nausea among males.

The phase IV clinical study analyzes what interactions people have when they take Levothroid and Septra. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Levothroid?

Levothroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 8,974 Levothroid users. Check the latest studies of Levothroid.

What is Septra?

Septra has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 10,280 Septra users. Check the latest studies of Septra.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 14, 2026

14 people who take Levothroid and Septra together, and have interactions are studied.

Levothroid and Septra drug interactions.

What are the common drug interactions of Levothroid and Septra, by gender? *:

female:

Abscess (pus)
Cellulitis (infection under the skin)
Epistaxis (bleed from the nose)
Fall
Foot fracture
Ligament sprain (ligament stretched)
Localised infection (infection at the single location)
Pain
Staphylococcal infection (an infection with staphylococcus bacteria)
Cholecystitis (infection of gallbladder)

male:

Nausea (feeling of having an urge to vomit)
Anxiety
Coma (state of unconsciousness lasting more than six hours)
Activities of daily living impaired
Asthenia (weakness)
Balance disorder
Cellulitis (infection under the skin)
Cerebral artery occlusion (blockage of blood vessel of brain by fat or clot)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Depression

What are the common drug interactions of Levothroid and Septra, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Abscess (pus)
Cellulitis (infection under the skin)
Epistaxis (bleed from the nose)
Fall
Foot fracture
Ligament sprain (ligament stretched)
Localised infection (infection at the single location)
Pain
Staphylococcal infection (an infection with staphylococcus bacteria)

50-59:

n/a

60+:

Nausea (feeling of having an urge to vomit)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Fatigue (feeling of tiredness)
Cholecystitis (infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Coma (state of unconsciousness lasting more than six hours)
Activities of daily living impaired
Asthenia (weakness)
Balance disorder
Cellulitis (infection under the skin)

What are the existing conditions these people have? *

Pain: 5 people, 35.71%
Osteoporosis (bones weak and more likely to break): 3 people, 21.43%
Neuropathy Peripheral (surface nerve damage): 3 people, 21.43%
Neuralgia (pain in one or more nerves): 3 people, 21.43%
Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 3 people, 21.43%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 2 people, 14.29%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 2 people, 14.29%
Nausea (feeling of having an urge to vomit): 1 person, 7.14%
Multiple Myeloma (cancer of the plasma cells): 1 person, 7.14%
Menstruation Irregular: 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

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