Levothroid and Simethicone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Levothroid (levothyroxine sodium) and Simethicone (simethicone). Common drug interactions include graft versus host disease among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Levothroid and Simethicone. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Levothroid?

Levothroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 8,974 Levothroid users. Check the latest studies of Levothroid.

What is Simethicone?

Simethicone has active ingredients of simethicone. It is often used in gas. eHealthMe is studying from 6,763 Simethicone users. Check the latest studies of Simethicone.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 29, 2026

23 people who take Levothroid and Simethicone together, and have interactions are studied.

Levothroid and Simethicone drug interactions.

What are the common drug interactions of Levothroid and Simethicone, by gender? *:

female:

Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Hypotension (abnormally low blood pressure)
Swelling face
Tremor (trembling or shaking movements in one or more parts of your body)
Weight decreased
Adverse drug reaction
Decreased appetite
Dehydration (dryness resulting from the removal of water)
Dry mouth
Full blood count decreased

male:

Chronic kidney disease
Drug ineffective
Pneumonia
Renal failure (kidney dysfunction)

What are the common drug interactions of Levothroid and Simethicone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Ascites (accumulation of fluid in the abdominal cavity)
Anaemia (lack of blood)
Presyncope

50-59:

Abdominal pain
Brain neoplasm (tumour of brain)
Central nervous system haemorrhage (bleeding in brain and surrounding)
Chronic kidney disease
Drug ineffective
Nausea (feeling of having an urge to vomit)
Pneumonia
Renal failure (kidney dysfunction)
Vomiting

60+:

Drug ineffective
Tremor (trembling or shaking movements in one or more parts of your body)
Fatigue (feeling of tiredness)
Full blood count decreased
Oedema (fluid collection in tissue)
Platelet count decreased
Rhinorrhoea (watery mucus discharge from the nose)
Weight decreased
Adverse drug reaction
Arterial disorder

What are the existing conditions these people have? *

Flatulence (flatus expelled through the anus): 8 people, 34.78%
Pain: 7 people, 30.43%
Neuralgia (pain in one or more nerves): 5 people, 21.74%
Lumbar Spinal Stenosis (a medical condition in which the spinal canal narrows and compresses the spinal cord and nerves at the level of the lumbar bone): 5 people, 21.74%
Sleep Disorder: 5 people, 21.74%
Piriformis Syndrome (neuromuscular disorder that occurs when the sciatic nerve is compressed): 5 people, 21.74%
Multiple Myeloma (cancer of the plasma cells): 4 people, 17.39%
Back Pain: 3 people, 13.04%
Acute Graft Versus Host Disease In Intestine (acute complication in intestine following an allogeneic tissue/blood transplant): 2 people, 8.70%
Ascites (accumulation of fluid in the abdominal cavity): 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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