Levothroid and Xenical drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Levothroid (levothyroxine sodium) and Xenical (orlistat). Common drug interactions include steatorrhoea among females and tinnitus among males.

The phase IV clinical study analyzes what interactions people have when they take Levothroid and Xenical. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Levothroid?

Levothroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 8,974 Levothroid users. Check the latest studies of Levothroid.

What is Xenical?

Xenical has active ingredients of orlistat. It is often used in weight loss. eHealthMe is studying from 11,722 Xenical users. Check the latest studies of Xenical.

On Jul, 26, 2026

15 people who take Levothroid and Xenical together, and have interactions are studied.

Levothroid and Xenical drug interactions.

What are the common drug interactions of Levothroid and Xenical, by gender? *:

female:

Steatorrhoea (presence of excess fat in faeces)
Diarrhoea
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Pain in limb
Abdominal distension
Abdominal pain lower
Abdominal pain upper
Alanine aminotransferase increased

male:

Tinnitus (a ringing in the ears)

What are the common drug interactions of Levothroid and Xenical, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Appetite increased (increased appetite is when you want to eat much more often or in larger quantities than your body requires)
Arthralgia (joint pain)
Menses delayed (delayed menstrual cycle)
Steatorrhoea (presence of excess fat in faeces)
Thirst
Weight increased

40-49:

Abdominal pain
Faeces discoloured
Flatulence (flatus expelled through the anus)
Frequent bowel movements
Steatorrhoea (presence of excess fat in faeces)
Constipation
Abdominal pain lower
Alanine aminotransferase increased
Arthralgia (joint pain)
Asthenia (weakness)

50-59:

Abdominal distension
Constipation
Diarrhoea
Hepatitis acute
Steatorrhoea (presence of excess fat in faeces)
Weight increased

60+:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Arthropathy
Hypertension (high blood pressure)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Nervous system disorder (a general class of medical conditions affecting the nervous system)
Pain
Tinnitus (a ringing in the ears)
Blood cholesterol increased
Blood potassium increased
Cardiac failure congestive

What are the existing conditions these people have? *

Depression: 2 people, 13.33%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

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