Levothroid and Zaroxolyn drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Levothroid (levothyroxine sodium) and Zaroxolyn (metolazone). Common drug interactions include drug ineffective among females and gastrointestinal haemorrhage among males.

The phase IV clinical study analyzes what interactions people have when they take Levothroid and Zaroxolyn. It is created by eHealthMe based on reports of 46 people who take the same drugs from the FDA, and is updated regularly.

What is Levothroid?

Levothroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 8,974 Levothroid users. Check the latest studies of Levothroid.

What is Zaroxolyn?

Zaroxolyn has active ingredients of metolazone. It is often used in high blood pressure. eHealthMe is studying from 5,244 Zaroxolyn users. Check the latest studies of Zaroxolyn.

On Jul, 13, 2026

46 people who take Levothroid and Zaroxolyn together, and have interactions are studied.

Levothroid and Zaroxolyn drug interactions.

What are the common drug interactions of Levothroid and Zaroxolyn, by gender? *:

female:

Drug ineffective
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Ecchymosis (a discoloration of the skin resulting from bleeding underneath)
Fatigue (feeling of tiredness)
Feeling hot
Fibromyalgia (a long-term condition which causes pain all over the body)
Flushing (the warm, red condition of human skin)
Formication (a sensation that exactly resembles that of small insects crawling on (or under) the skin)
Generalised oedema (swelling all over the body)
Glomerular filtration rate decreased

male:

Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Blood alkaline phosphatase nos increased
Pulmonary embolism (blockage of the main artery of the lung)
Pulseless electrical activity
Shock haemorrhagic (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin due to excess bleeding)
Alanine aminotransferase increased
Asthenia (weakness)
Blood bilirubin increased
Cardiac failure
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)

What are the common drug interactions of Levothroid and Zaroxolyn, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Depressed mood
Somnolence (a state of near-sleep, a strong desire for sleep)
Therapeutic response unexpected

50-59:

Swelling
Cold sweat
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Drug ineffective
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Formication (a sensation that exactly resembles that of small insects crawling on (or under) the skin)
Heart disease
Nausea (feeling of having an urge to vomit)
Stomach discomfort (pain in abdomen)

60+:

Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Dyspnoea (difficult or laboured respiration)
Cough
Death
Decreased appetite
Gamma-glutamyltransferase increased
Haematoma (collection of blood outside the blood vessels)
Hypotension (abnormally low blood pressure)
Incoherent (talking in a confused and unclear way)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)

What are the existing conditions these people have? *

Pain: 13 people, 28.26%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 13 people, 28.26%
Dyspnea (difficult or laboured breathing): 7 people, 15.22%
Type 2 Diabetes: 4 people, 8.70%
Stress And Anxiety: 4 people, 8.70%
Fever: 4 people, 8.70%
Diabetes: 4 people, 8.70%
Constipation: 4 people, 8.70%
Rashes (redness): 3 people, 6.52%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 3 people, 6.52%

* Approximation only. Some reports may have incomplete information.

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