Levoxyl and Ddavp drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Levoxyl (levothyroxine sodium) and Ddavp (desmopressin acetate). Common drug interactions include swelling among females and sleep apnoea syndrome among males.

The phase IV clinical study analyzes what interactions people have when they take Levoxyl and Ddavp. It is created by eHealthMe based on reports of 84 people who take the same drugs from the FDA, and is updated regularly.

What is Levoxyl?

Levoxyl has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 25,178 Levoxyl users. Check the latest studies of Levoxyl.

What is Ddavp?

Ddavp has active ingredients of desmopressin acetate. It is often used in diabetes insipidus. eHealthMe is studying from 2,614 Ddavp users. Check the latest studies of Ddavp.

On Jul, 10, 2026

84 people who take Levoxyl and Ddavp together, and have interactions are studied.

What are the common drug interactions of Levoxyl and Ddavp, by gender? *:

female:

Swelling
Alopecia (absence of hair from areas of the body)
Appendicitis (inflammation of the appendix)
Chest pain
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Diabetes mellitus inadequate control
Glycosylated haemoglobin increased
Hospitalisation
Loss of consciousness
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)

male:

Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Craniopharyngioma (a type of brain tumour derived from pituitary gland embryonic tissue)
Polyuria (production of too much dilute urine)
Abdominal pain
Acanthosis nigricans (skin disease-dark warlike patches in the body folds)
Acute myocardial infarction (acute heart attack)
Agitation (state of anxiety or nervous excitement)
Anxiety
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)

What are the common drug interactions of Levoxyl and Ddavp, by age (0-1 to 60+)? *:

0-1:

Agitation (state of anxiety or nervous excitement)
Crying
Insomnia (sleeplessness)
Nervousness
Screaming (a long loud piercing cry)
Abnormal behaviour
Irritability
Sepsis (a severe blood infection that can lead to organ failure and death)

2-9:

Disease recurrence
Eye swelling
Headache (pain in head)
Incision site abscess
Incision site cellulitis (spreading bacterial skin infection at incision site)
Incision site erythema (redness of the skin at incision site)
Incontinence (lack of moderation or self-control)
Nausea (feeling of having an urge to vomit)
Neoplasm recurrence (reoccurrence of tumour)
Nervous system disorder (a general class of medical conditions affecting the nervous system)

10-19:

Weight increased
Asthenia (weakness)
Balance disorder
Gait disturbance
Hypersensitivity
Hypoglycaemia (deficiency of glucose in the bloodstream)
Neoplasm recurrence (reoccurrence of tumour)
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Polydipsia (excessive thirst)
Polyuria (production of too much dilute urine)

20-29:

Aortic valve incompetence
Adrenocortical insufficiency acute (suddenly adrenal glands do not produce adequate amounts of steroid hormones)
Alopecia (absence of hair from areas of the body)
Anxiety
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Gastroenteritis (inflammation of stomach and intestine)
Headache (pain in head)
Liver injury
Migraine (headache)
Nasopharyngitis (inflammation of the nasopharynx)

30-39:

Cough
Fatigue (feeling of tiredness)
Pain
Upper-airway cough syndrome
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Abdominal pain
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Dehydration (dryness resulting from the removal of water)
Glycosylated haemoglobin increased
Loss of consciousness

40-49:

Chest pain
Diabetes mellitus inadequate control
Hyperhidrosis (abnormally increased sweating)
Nausea (feeling of having an urge to vomit)
Weight increased
Binge eating (pattern of disordered eating which consists of episodes of uncontrollable eating)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Neoplasm (tumour)
Vaginal haemorrhage (vaginal bleeding)

50-59:

Arthralgia (joint pain)
Abdominal pain
Blood glucose increased
Nausea (feeling of having an urge to vomit)
Platelet count decreased
Pyrexia (fever)
Red blood cells urine positive
Urine ketone body present
Vomiting
White blood cell count increased

60+:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Joint swelling
Multi-organ failure (multisystem organ failure)
Nervousness
Oedema (fluid collection in tissue)
Oedema peripheral (superficial swelling)
Pain
Renal failure (kidney dysfunction)
Renal injury (kidney injury)

What are the existing conditions these people have? *

Hypopituitarism (diminished hormone secretion by the pituitary gland, causing dwarfism in children and premature aging in adults): 22 people, 26.19%
Stress And Anxiety: 6 people, 7.14%
Osteoporosis (bones weak and more likely to break): 6 people, 7.14%
Depression: 6 people, 7.14%
Neuralgia (pain in one or more nerves): 5 people, 5.95%
Neck Pain: 5 people, 5.95%
Muscle Spasms (muscle contraction): 5 people, 5.95%
Joint Pain: 5 people, 5.95%
Growth Hormone Deficiency: 5 people, 5.95%
Fibromyalgia (a long-term condition which causes pain all over the body): 5 people, 5.95%

* Approximation only. Some reports may have incomplete information.

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