Levoxyl and Femara drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Levoxyl (levothyroxine sodium) and Femara (letrozole). Common drug interactions include bone lesion among females and anaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Levoxyl and Femara. It is created by eHealthMe based on reports of 98 people who take the same drugs from the FDA, and is updated regularly.

What is Levoxyl?

Levoxyl has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 25,178 Levoxyl users. Check the latest studies of Levoxyl.

What is Femara?

Femara has active ingredients of letrozole. It is often used in breast cancer. eHealthMe is studying from 19,630 Femara users. Check the latest studies of Femara.

On Jul, 09, 2026

98 people who take Levoxyl and Femara together, and have interactions are studied.

What are the common drug interactions of Levoxyl and Femara, by gender? *:

female:

Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Mitral valve incompetence (inefficient heart valve)
Tricuspid valve incompetence (inefficient heart valve)
Urinary tract infection
Osteoporosis (bones weak and more likely to break)
Arthralgia (joint pain)
Pain in extremity
Constipation
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

male:

Anaemia (lack of blood)
Anxiety
Vomiting
Altered state of consciousness (altered state of mind)
Aortic dilatation
Asthenia (weakness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bone disorder
Death
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)

What are the common drug interactions of Levoxyl and Femara, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal pain upper
Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)
Adjustment disorder
Alopecia (absence of hair from areas of the body)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anxiety
Arthralgia (joint pain)
Asthma
Axillary pain
Back pain

40-49:

Abdominal pain upper
Anxiety
Back pain
Blood cholesterol increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Chest pain
Chills (felling of cold)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Constipation
Depression

50-59:

Osteolysis (dissolution of bone)
Pulmonary congestion (congestion in the lungs)
Dyspnoea (difficult or laboured respiration)
Nausea (feeling of having an urge to vomit)
Back pain
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Hypertension (high blood pressure)
Oedema peripheral (superficial swelling)
Dental caries
Gait disturbance

60+:

Nausea (feeling of having an urge to vomit)
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Bone disorder
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Confusional state
Mitral valve calcification (calcium deposit in mitral valve)
Renal failure (kidney dysfunction)
Swelling
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Chest discomfort

What are the existing conditions these people have? *

Breast Cancer Metastatic: 29 people, 29.59%
Irritable Bowel Syndrome: 27 people, 27.55%
Pain: 15 people, 15.31%
Thyroid Diseases: 10 people, 10.20%
Depression: 7 people, 7.14%
Neuropathy Peripheral (surface nerve damage): 5 people, 5.10%
High Blood Pressure: 5 people, 5.10%

* Approximation only. Some reports may have incomplete information.

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