Levoxyl and Maxalt drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Levoxyl (levothyroxine sodium) and Maxalt (rizatriptan benzoate). Common drug interactions include malaise among females and arthralgia among males.

The phase IV clinical study analyzes what interactions people have when they take Levoxyl and Maxalt. It is created by eHealthMe based on reports of 91 people who take the same drugs from the FDA, and is updated regularly.

What is Levoxyl?

Levoxyl has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 25,178 Levoxyl users. Check the latest studies of Levoxyl.

What is Maxalt?

Maxalt has active ingredients of rizatriptan benzoate. It is often used in migraine. eHealthMe is studying from 12,754 Maxalt users. Check the latest studies of Maxalt.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

91 people who take Levoxyl and Maxalt together, and have interactions are studied.

What are the common drug interactions of Levoxyl and Maxalt, by gender? *:

female:

Malaise (a feeling of general discomfort or uneasiness)
Mobility decreased (ability to move is reduced)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Osteonecrosis (death of bone)
Pruritus (severe itching of the skin)
Skin lesion
Tremor (trembling or shaking movements in one or more parts of your body)
Trigeminal neuralgia (a painful condition of the nerve responsible for most facial sensation)
Vomiting
Actinomycosis (infection that causes sores, or abscesses)

male:

Arthralgia (joint pain)
Back pain
Anion gap increased
Ankle fracture
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Arthropathy
Asthenia (weakness)
Biliary dilatation
Bipolar disorder (mood disorder)
Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode)

What are the common drug interactions of Levoxyl and Maxalt, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Abdominal pain upper
Ankle fracture
Arthropathy
Bipolar disorder (mood disorder)
Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode)
Bronchitis chronic (inflammation of the mucous membrane in the bronchial tubes- chronic)
Cardiac arrest
Cardiac disorder
Cardiomegaly (increased size of heart than normal)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)

10-19:

n/a

20-29:

Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Biliary dilatation
Bone disorder
Bone pain
Calcium deficiency (lack of calcium)
Cataract (clouding of the lens inside the eye)
Cholangitis (infection of the bile duct)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)

30-39:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Pulmonary embolism (blockage of the main artery of the lung)
Abdominal pain
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Constipation
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Drug addiction
Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain)
Hallucination (an experience involving the perception of something not present)
Hot flush (sudden feelings of heat)

40-49:

Anxiety
Depression
Insomnia (sleeplessness)
Osteomyelitis (infection of bone)
Asthma
Sinusitis (inflammation of sinus)
Upper respiratory tract infection
Wisdom teeth removal
Adverse drug reaction
Cellulitis (infection under the skin)

50-59:

Feeling cold
Glaucoma (increased fluid pressure in the eye with vision loss)
Injection site swelling
Injection site urticaria (rash of round, red welts on the skin at injection site)
Insomnia (sleeplessness)
Intervertebral disc degeneration (spinal disc degeneration)
Irritability
Joint injury
Joint swelling
Loss of consciousness

60+:

Fall
Mobility decreased (ability to move is reduced)
Abdominal pain
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Alopecia (absence of hair from areas of the body)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Burning sensation
Chest pain
Chills (felling of cold)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 14 people, 15.38%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 10 people, 10.99%
Thyroid Diseases: 7 people, 7.69%
Stress And Anxiety: 6 people, 6.59%
Sleep Disorder: 6 people, 6.59%
Primary Immunodeficiency Syndrome: 6 people, 6.59%
Osteoporosis (bones weak and more likely to break): 6 people, 6.59%
Immunodeficiency Common Variable: 6 people, 6.59%
High Blood Pressure: 6 people, 6.59%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 6.59%

* Approximation only. Some reports may have incomplete information.

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