Levoxyl and Rocaltrol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Levoxyl (levothyroxine sodium) and Rocaltrol (calcitriol). Common drug interactions include osteoarthritis among females and muscular weakness among males.

The phase IV clinical study analyzes what interactions people have when they take Levoxyl and Rocaltrol. It is created by eHealthMe based on reports of 37 people who take the same drugs from the FDA, and is updated regularly.

What is Levoxyl?

Levoxyl has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 25,178 Levoxyl users. Check the latest studies of Levoxyl.

What is Rocaltrol?

Rocaltrol has active ingredients of calcitriol. It is often used in hypoparathyroidism. eHealthMe is studying from 7,562 Rocaltrol users. Check the latest studies of Rocaltrol.

On Jul, 18, 2026

37 people who take Levoxyl and Rocaltrol together, and have interactions are studied.

Levoxyl and Rocaltrol drug interactions.

What are the common drug interactions of Levoxyl and Rocaltrol, by gender? *:

female:

Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Shoulder pain
Sinus congestion (blockage of sinus)
Sleep disorder
Swelling
Thrombosis (formation of a blood clot inside a blood vessel)
Anaemia (lack of blood)
Arteriovenous fistula site haematoma (collection of blood outside of the blood vessels, which gathers at av fistula site)
Arteriovenous fistula site infection
Arthropathy

male:

Muscular weakness (muscle weakness)
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Drug toxicity
Exostosis (formation of new bone on the surface of a bone)
Fluid overload (too much fluid in the blood)
Gallbladder disorder
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Injury
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Neuropathy peripheral (surface nerve damage)

What are the common drug interactions of Levoxyl and Rocaltrol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Platelet count decreased

10-19:

n/a

20-29:

n/a

30-39:

Asthenia (weakness)
Blood pressure inadequately controlled
Fall
Headache (pain in head)
Hypertension (high blood pressure)
Hypotonia (low muscle tone)
Muscular weakness (muscle weakness)

40-49:

Oedema peripheral (superficial swelling)
Rash erythematous (redness of the skin)
Rash papular (redness with papule)
Arthralgia (joint pain)
Bone pain
Dry skin
Muscular weakness (muscle weakness)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Oedema (fluid collection in tissue)
Pain in extremity

50-59:

Hypoaesthesia (reduced sense of touch or sensation)
Induration (thickening of tissue)
Joint stiffness
Mitral valve disease (disease of mitral valve of heart)
Mobility decreased (ability to move is reduced)
Muscle tightness
Muscular weakness (muscle weakness)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Oedema peripheral (superficial swelling)

60+:

Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Thrombosis (formation of a blood clot inside a blood vessel)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Conjunctivitis (pink eye)
Diarrhoea
Diverticulum intestinal (a pouch that is attached to the first part of the small intestine)
Drug toxicity
Exostosis (formation of new bone on the surface of a bone)
Fluid overload (too much fluid in the blood)
Gallbladder disorder

What are the existing conditions these people have? *

Nuclear Magnetic Resonance Imaging Brain: 8 people, 21.62%
Nuclear Magnetic Resonance Imaging Abdominal: 5 people, 13.51%
Pain: 4 people, 10.81%
Oedema Peripheral (superficial swelling): 4 people, 10.81%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 10.81%
Stress And Anxiety: 3 people, 8.11%
Rickets (softening of bones): 3 people, 8.11%
Headache (pain in head): 3 people, 8.11%
Bone Pain: 3 people, 8.11%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 2 people, 5.41%

* Approximation only. Some reports may have incomplete information.

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