Levoxyl and Vivelle-dot drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Levoxyl (levothyroxine sodium) and Vivelle-dot (estradiol). Common drug interactions include arthritis among females.

The phase IV clinical study analyzes what interactions people have when they take Levoxyl and Vivelle-dot. It is created by eHealthMe based on reports of 58 people who take the same drugs from the FDA, and is updated regularly.

What is Levoxyl?

Levoxyl has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 25,178 Levoxyl users. Check the latest studies of Levoxyl.

What is Vivelle-dot?

Vivelle-dot has active ingredients of estradiol. It is often used in hormone replacement therapy. eHealthMe is studying from 3,545 Vivelle-dot users. Check the latest studies of Vivelle-dot.

On Jul, 14, 2026

58 people who take Levoxyl and Vivelle-dot together, and have interactions are studied.

Levoxyl and Vivelle-dot drug interactions.

What are the common drug interactions of Levoxyl and Vivelle-Dot, by gender? *:

female:

Arthritis (form of joint disorder that involves inflammation of one or more joints)
Breast cancer
Fatigue (feeling of tiredness)
Memory impairment
Abdominal distension
Anger
Bruxism (habitual grinding of the teeth, typically during sleep)
Crying
Decreased activity
Dizziness

male:

n/a

What are the common drug interactions of Levoxyl and Vivelle-Dot, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Cough
Fatigue (feeling of tiredness)
Pain
Upper-airway cough syndrome
Adrenocortical insufficiency acute (suddenly adrenal glands do not produce adequate amounts of steroid hormones)

40-49:

Muscle spasms (muscle contraction)
Neck pain
Rash
Sinusitis (inflammation of sinus)

50-59:

Myalgia (muscle pain)
Nausea (feeling of having an urge to vomit)
Pain
Pyrexia (fever)
Reverse tri-iodothyronine increased
Stress
Weight decreased
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Breast cancer
Memory impairment

60+:

Drug ineffective
Fatigue (feeling of tiredness)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Asthenia (weakness)
Asthma
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Back injury
Blood pressure fluctuation
Breast adenoma (breast tumour)
Breast calcifications (deposits of calcium that can be seen on a mammogram of the breast)

What are the existing conditions these people have? *

High Blood Pressure: 23 people, 39.66%
Hot Flush (sudden feelings of heat): 21 people, 36.21%
Depression: 21 people, 36.21%
Menopause (end of monthly cycles in women): 18 people, 31.03%
Back Pain: 15 people, 25.86%
High Blood Cholesterol: 12 people, 20.69%
Irritable Bowel Syndrome: 10 people, 17.24%
Menopausal Symptoms: 8 people, 13.79%
Breast Cancer: 8 people, 13.79%
Cough: 4 people, 6.90%

* Approximation only. Some reports may have incomplete information.

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