Lialda and Aleve drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lialda (mesalamine) and Aleve (naproxen sodium). Common drug interactions include drug ineffective among females and abdominal distension among males.

The phase IV clinical study analyzes what interactions people have when they take Lialda and Aleve. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.

What is Lialda?

Lialda has active ingredients of mesalamine. It is often used in ulcerative colitis. eHealthMe is studying from 10,199 Lialda users. Check the latest studies of Lialda.

What is Aleve?

Aleve has active ingredients of naproxen sodium. It is often used in pain. eHealthMe is studying from 70,279 Aleve users. Check the latest studies of Aleve.

On Jul, 15, 2026

27 people who take Lialda and Aleve together, and have interactions are studied.

What are the common drug interactions of Lialda and Aleve, by gender? *:

female:

Drug ineffective
Diarrhoea
Arthralgia (joint pain)
Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Pain in extremity
Post procedural complication
Asthenia (weakness)
Dry skin
Dry throat

male:

Abdominal distension
Nausea (feeling of having an urge to vomit)
Dizziness
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Erythema (redness of the skin)
Fatigue (feeling of tiredness)
Flatulence (flatus expelled through the anus)
Hypersensitivity
Ileus (a painful obstruction of the ileum or other part of the intestine)

What are the common drug interactions of Lialda and Aleve, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Post procedural complication
Bone pain
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Diarrhoea
Fatigue (feeling of tiredness)
Glaucoma (increased fluid pressure in the eye with vision loss)
Oedema peripheral (superficial swelling)
Pain in extremity
Pulmonary embolism (blockage of the main artery of the lung)
Thrombophlebitis superficial (swelling (inflammation) of a superficial vein caused by a blood clot)

30-39:

Abnormal faeces (abnormal stool)
Depressed mood
Diarrhoea
Fatigue (feeling of tiredness)
Injection site bruising
Injection site swelling

40-49:

Abdominal pain lower
Anaphylactic reaction (serious allergic reaction)
Cough
Diarrhoea
Drug eruption (adverse drug reaction of the skin)
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Haemorrhage subcutaneous (bleeding from skin)
Insomnia (sleeplessness)

50-59:

Asthenia (weakness)
Dizziness
Dizziness postural
Erythema (redness of the skin)
Fatigue (feeling of tiredness)
Herpes zoster
Hypersensitivity
Infusion related reaction
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Nausea (feeling of having an urge to vomit)

60+:

Drug ineffective
Diarrhoea
Anaemia (lack of blood)
Apallic syndrome (serious brain damage, when cortical parts of the brain are disconnected from brainstem)
Aphonia (inability to produce voice)
Arthralgia (joint pain)
Asthenia (weakness)
Bacterial sepsis
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Chest pain

What are the existing conditions these people have? *

Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 6 people, 22.22%
High Blood Pressure: 3 people, 11.11%
Colitis (inflammation of colon): 3 people, 11.11%
Tendonitis (a condition that causes pain and swelling of tendons): 2 people, 7.41%
High Blood Cholesterol: 2 people, 7.41%
Back Pain: 2 people, 7.41%

* Approximation only. Some reports may have incomplete information.

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