Librium and Humira drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Librium (chlordiazepoxide hydrochloride) and Humira (adalimumab). Common drug interactions include memory impairment among females and upper gastrointestinal haemorrhage among males.

The phase IV clinical study analyzes what interactions people have when they take Librium and Humira. It is created by eHealthMe based on reports of 64 people who take the same drugs from the FDA, and is updated regularly.

What is Librium?

Librium has active ingredients of chlordiazepoxide hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 2,490 Librium users. Check the latest studies of Librium.

What is Humira?

Humira has active ingredients of adalimumab. It is often used in rheumatoid arthritis. eHealthMe is studying from 761,396 Humira users. Check the latest studies of Humira.



On Jul, 19, 2026

64 people who take Librium and Humira together, and have interactions are studied.

Librium and Humira drug interactions.

What are the common drug interactions of Librium and Humira, by gender? *:

female:

  1. Memory impairment
  2. Muscle twitching
  3. Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
  4. Nasopharyngitis (inflammation of the nasopharynx)
  5. Abdominal discomfort
  6. Abdominal pain upper
  7. Activities of daily living impaired
  8. Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
  9. Blood pressure increased
  10. Bone erosion

male:

  1. Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)
  2. Varices oesophageal (enlarged and swollen veins at the bottom of the oesophagus, near the stomach)
  3. Hypokalaemia (low potassium)
  4. Cirrhosis alcoholic (chronic disease of the liver marked by degeneration of cells, inflammation, and fibrous thickening of tissue caused by alcoholism)
  5. Blood potassium decreased
  6. Gastric disorder (disease of stomach)
  7. Osteoarthritis (a joint disease caused by cartilage loss in a joint)
  8. Upper limb fracture
  9. Ascites (accumulation of fluid in the abdominal cavity)
  10. Encephalopathy (functioning of the brain is affected by some agent or condition)

What are the common drug interactions of Librium and Humira, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Abdominal pain upper
  2. Arthralgia (joint pain)
  3. Arthritis (form of joint disorder that involves inflammation of one or more joints)
  4. Chest discomfort
  5. Fatigue (feeling of tiredness)
  6. Nasopharyngitis (inflammation of the nasopharynx)
  7. Nausea (feeling of having an urge to vomit)
  8. Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
  9. Spinal osteoarthritis (joint cartilage loss in spine)
  10. Contusion (a type of hematoma of tissue in which capillaries)

40-49:

  1. Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)
  2. Mycobacterial infection
  3. Pneumonia
  4. Biliary sepsis
  5. Escherichia infection (bacterial infection by escherichia coli)
  6. Hypokalaemia (low potassium)
  7. Varices oesophageal (enlarged and swollen veins at the bottom of the oesophagus, near the stomach)
  8. Blood potassium decreased
  9. Gastric disorder (disease of stomach)
  10. Bone pain

50-59:

  1. Pain in extremity
  2. Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)
  3. Speech disorder
  4. Vitamin b12 increased
  5. Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
  6. Arthralgia (joint pain)
  7. Back pain
  8. Body temperature increased
  9. Diarrhoea
  10. Drug effect decreased

60+:

  1. Arthritis (form of joint disorder that involves inflammation of one or more joints)
  2. Joint swelling
  3. Weight increased
  4. Alopecia (absence of hair from areas of the body)
  5. Memory impairment
  6. Muscle twitching
  7. Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
  8. Nasopharyngitis (inflammation of the nasopharynx)
  9. Abdominal pain upper
  10. Activities of daily living impaired

What are the existing conditions these people have? *

  1. Psoriasis (immune-mediated disease that affects the skin): 29 people, 45.31%
  2. Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 9 people, 14.06%
  3. Pain: 8 people, 12.50%
  4. Depression: 6 people, 9.38%
  5. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 4 people, 6.25%
  6. Migraine (headache): 4 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Librium and Humira:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Librium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Humira:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Librium and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Humira and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on chlordiazepoxide hydrochloride and adalimumab (the active ingredients of Librium and Humira, respectively), and Librium and Humira (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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