Librium and Thiamine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Librium (chlordiazepoxide hydrochloride) and Thiamine (thiamine (vitamin b1)). Common drug interactions include diabetic complication among females and abdominal pain upper among males.

The phase IV clinical study analyzes what interactions people have when they take Librium and Thiamine. It is created by eHealthMe based on reports of 57 people who take the same drugs from the FDA, and is updated regularly.

What is Librium?

Librium has active ingredients of chlordiazepoxide hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 2,490 Librium users. Check the latest studies of Librium.

What is Thiamine?

Thiamine has active ingredients of thiamine (vitamin b1). eHealthMe is studying from 11,036 Thiamine users. Check the latest studies of Thiamine.



On Jul, 04, 2026

57 people who take Librium and Thiamine together, and have interactions are studied.

Librium and Thiamine drug interactions.

What are the common drug interactions of Librium and Thiamine, by gender? *:

female:

  1. Diabetic complication
  2. Dizziness
  3. Forearm fracture (fracture in between wrist to elbow)
  4. Hyperlipidaemia (presence of excess lipids in the blood)
  5. Joint effusion (presence of extra fluid in joint covering)
  6. Malaise (a feeling of general discomfort or uneasiness)
  7. Post-traumatic stress disorder
  8. Suicide attempt
  9. Synovitis (inflammation of the synovial membrane)
  10. Type 2 diabetes mellitus

male:

  1. Abdominal pain upper
  2. Diarrhoea
  3. Haematoma (collection of blood outside the blood vessels)
  4. Rectal haemorrhage (bleeding from anus)
  5. Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)
  6. Varices oesophageal (enlarged and swollen veins at the bottom of the oesophagus, near the stomach)
  7. Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
  8. Cirrhosis alcoholic (chronic disease of the liver marked by degeneration of cells, inflammation, and fibrous thickening of tissue caused by alcoholism)
  9. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  10. Biliary sepsis

What are the common drug interactions of Librium and Thiamine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Blood pressure decreased
  2. Heart rate decreased

30-39:

  1. Emotional distress
  2. Pain
  3. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  4. Arthralgia (joint pain)
  5. Chronic kidney disease
  6. Depression
  7. Fracture
  8. Fractured sacrum
  9. Gait disturbance
  10. Hip fracture

40-49:

  1. Hallucination, visual (seeing things that aren't there)
  2. Headache (pain in head)
  3. Hyperhidrosis (abnormally increased sweating)
  4. Injection site pain
  5. Injection site reaction
  6. Insomnia (sleeplessness)
  7. Intentional self-injury
  8. Lethargy (tiredness)
  9. Malaise (a feeling of general discomfort or uneasiness)
  10. Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)

50-59:

  1. Abdominal pain upper
  2. Diarrhoea
  3. Dysphagia (a condition in which swallowing is difficult or painful)
  4. Malaise (a feeling of general discomfort or uneasiness)
  5. Pyrexia (fever)
  6. Vomiting
  7. Haematemesis (vomiting of blood)
  8. Haematoma (collection of blood outside the blood vessels)
  9. Rectal haemorrhage (bleeding from anus)
  10. Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)

60+:

  1. Application site rash
  2. Arthritis bacterial (form of joint disorder that involves inflammation of one or more joints due to bacterial infection)
  3. Fall
  4. Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  5. Haematoma infection (infection with collection of blood outside the blood vessels)
  6. Haemorrhagic anaemia (anaemia due to excessive bleeding)
  7. Hypoxia (low oxygen in tissues)
  8. International normalised ratio increased
  9. Laceration (tearing of soft body tissue)
  10. Loss of consciousness

What are the existing conditions these people have? *

  1. Psoriasis (immune-mediated disease that affects the skin): 16 people, 28.07%
  2. Pain: 14 people, 24.56%
  3. High Blood Pressure: 12 people, 21.05%
  4. Thrombosis (formation of a blood clot inside a blood vessel): 10 people, 17.54%
  5. Alcoholism (problems with alcohol): 6 people, 10.53%
  6. Hiv Infection: 5 people, 8.77%
  7. Depression: 5 people, 8.77%
  8. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 5.26%
  9. Essential Hypertension (primary hypertension): 3 people, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Librium and Thiamine?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Librium and Thiamine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Librium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Thiamine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Librium and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Thiamine and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on chlordiazepoxide hydrochloride and thiamine (vitamin b1) (the active ingredients of Librium and Thiamine, respectively), and Librium and Thiamine (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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