Limbitrol and Ibu drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Limbitrol (amitriptyline hydrochloride; chlordiazepoxide) and Ibu (ibuprofen). Common drug interactions include anaemia among females and hypoaesthesia among males.

The phase IV clinical study analyzes what interactions people have when they take Limbitrol and Ibu. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Limbitrol?

Limbitrol has active ingredients of amitriptyline hydrochloride; chlordiazepoxide. It is often used in stress and anxiety. eHealthMe is studying from 378 Limbitrol users. Check the latest studies of Limbitrol.

What is Ibu?

Ibu has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 246,532 Ibu users. Check the latest studies of Ibu.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Jul, 03, 2026

19 people who take Limbitrol and Ibu together, and have interactions are studied.

What are the common drug interactions of Limbitrol and Ibu, by gender? *:

female:

Anaemia (lack of blood)
Aspartate aminotransferase increased
Blood cholesterol increased
Blood triglycerides increased
C-reactive protein increased
Dependence
Depression
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Drug addiction
Eye pain

male:

Hypoaesthesia (reduced sense of touch or sensation)
Adenocarcinoma (malignant tumour formed from glandular structures in epithelial tissue)
Decreased interest
Depression
Dyspepsia (indigestion)
Fatigue (feeling of tiredness)
Foot fracture
General physical health deterioration (weak health status)
Gingival disorder (gum disease)
Hand fracture

What are the common drug interactions of Limbitrol and Ibu, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Blood cholesterol increased
Blood triglycerides increased
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Eye pain
Fatigue (feeling of tiredness)
Hypoaesthesia (reduced sense of touch or sensation)
Lipids increased (excess lipid in body)
Micturition urgency (urgency to pass the urine)

40-49:

Chronic kidney disease
Renal injury (kidney injury)

50-59:

Malaise (a feeling of general discomfort or uneasiness)
Pneumonia viral
Pyrexia (fever)

60+:

Anaemia (lack of blood)
C-reactive protein increased
Myelopathy (any neurologic deficit related to the spinal cord)
Neck pain
Peroneal nerve palsy
Skin irritation
Weakness
Cervical spinal stenosis (narrowing of the spinal canal in the neck)
Demyelinating polyneuropathy (disorder that affects the nerves outside of the brain and spinal cord (peripheral nerves))
Difficulty in walking

What are the existing conditions these people have? *

Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 1 person, 5.26%
Migraine (headache): 1 person, 5.26%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

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