Linzess and Combigan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Linzess (linaclotide) and Combigan (brimonidine tartrate; timolol maleate). Common drug interactions include diarrhoea among females and fall among males.

The phase IV clinical study analyzes what interactions people have when they take Linzess and Combigan. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Linzess?

Linzess has active ingredients of linaclotide. It is often used in constipation. eHealthMe is studying from 24,086 Linzess users. Check the latest studies of Linzess.

What is Combigan?

Combigan has active ingredients of brimonidine tartrate; timolol maleate. It is often used in glaucoma. eHealthMe is studying from 7,810 Combigan users. Check the latest studies of Combigan.

On Jul, 10, 2026

38 people who take Linzess and Combigan together, and have interactions are studied.

What are the common drug interactions of Linzess and Combigan, by gender? *:

female:

Diarrhoea
Fatigue (feeling of tiredness)
Back pain
Micturition urgency (urgency to pass the urine)
Abdominal distension
Abdominal discomfort
Eye irritation
Abdominal pain
Flatulence (flatus expelled through the anus)
Arthralgia (joint pain)

male:

Fall
Mobility decreased (ability to move is reduced)
Coronavirus test positive
Death
Depression
Drug hypersensitivity
Hospitalisation
Hypotension (abnormally low blood pressure)
Influenza
Influenza like illness

What are the common drug interactions of Linzess and Combigan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Fall
Mobility decreased (ability to move is reduced)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Tooth disorder (tooth disease)
Depression
Fatigue (feeling of tiredness)
Abdominal distension
Drug ineffective
Weight increased

50-59:

n/a

60+:

Fatigue (feeling of tiredness)
Diarrhoea
Erythema (redness of the skin)
Hospitalisation
Hypotension (abnormally low blood pressure)
Influenza
Influenza like illness
Pruritus (severe itching of the skin)
Swollen tongue (swelling of tongue)
Weight fluctuation

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 9 people, 23.68%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 13.16%
Parkinson's Disease: 3 people, 7.89%
Irritable Bowel Syndrome: 3 people, 7.89%
Neurotrophic Keratopathy (decreased corneal sensitivity and poor corneal healing): 2 people, 5.26%
Hereditary Neuropathic Amyloidosis (hereditary- diseases resulting from abnormal deposition of certain proteins (amyloid) in various bodily areas by problems with signals from the nerves): 2 people, 5.26%
Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 2 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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