Linzess and Insulin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Linzess (linaclotide) and Insulin (insulin pork). Common drug interactions include depression among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Linzess and Insulin. It is created by eHealthMe based on reports of 74 people who take the same drugs from the FDA, and is updated regularly.

What is Linzess?

Linzess has active ingredients of linaclotide. It is often used in constipation. eHealthMe is studying from 24,086 Linzess users. Check the latest studies of Linzess.

What is Insulin?

Insulin has active ingredients of insulin pork. It is often used in diabetes. eHealthMe is studying from 50,203 Insulin users. Check the latest studies of Insulin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

74 people who take Linzess and Insulin together, and have interactions are studied.

What are the common drug interactions of Linzess and Insulin, by gender? *:

female:

Depression
Disturbance in attention
Drug effect decreased
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea exertional (breathlessness or shortness of breath)
Emotional distress
Erythema (redness of the skin)
Eye pruritus (eye itching)
Fibromyalgia (a long-term condition which causes pain all over the body)
Foaming at mouth (excess saliva secretion)

male:

Drug ineffective
Diarrhoea
Abdominal discomfort
Abdominal distension
Dry mouth
Haemoglobin decreased
Abdominal pain
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Blood pressure decreased
Bowel movement irregularity

What are the common drug interactions of Linzess and Insulin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal discomfort
Abdominal pain upper
Aggression
Anxiety
Asthenia (weakness)
Blood glucose decreased
Depression
Fatigue (feeling of tiredness)
Insomnia (sleeplessness)
Tremor (trembling or shaking movements in one or more parts of your body)

30-39:

Post procedural complication
Skin disorder (skin disease)
Abscess (pus)
Erythema (redness of the skin)
Immunodeficiency
Pain

40-49:

Blood glucose increased
Bone pain
Fluid retention (an abnormal accumulation of fluid in the blood)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Irritability
Malaise (a feeling of general discomfort or uneasiness)
Stomatitis (inflammation of mucous membrane of mouth)
Vulvovaginal discomfort

50-59:

Drug intolerance (drug sensitivity)
Dyspnoea (difficult or laboured respiration)
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
Headache (pain in head)
Influenza like illness
Pain
Paranasal sinus discomfort
Chest pain
Chronic kidney disease
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)

60+:

Drug ineffective
Arthralgia (joint pain)
Abdominal distension
Abdominal pain
Bowel movement irregularity
Energy increased
Fatigue (feeling of tiredness)
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
Hypoaesthesia (reduced sense of touch or sensation)
Overdose

What are the existing conditions these people have? *

High Blood Pressure: 13 people, 17.57%
Irritable Bowel Syndrome: 11 people, 14.86%
Pain: 10 people, 13.51%
Type 2 Diabetes: 8 people, 10.81%
Nausea (feeling of having an urge to vomit): 7 people, 9.46%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 9.46%
High Blood Cholesterol: 6 people, 8.11%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 6 people, 8.11%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 5 people, 6.76%
Sleep Disorder: 4 people, 5.41%

* Approximation only. Some reports may have incomplete information.

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