Linzess and Librax drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Linzess (linaclotide) and Librax (chlordiazepoxide hydrochloride; clidinium bromide). Common drug interactions include diarrhoea among females and dyspepsia among males.

The phase IV clinical study analyzes what interactions people have when they take Linzess and Librax. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Linzess?

Linzess has active ingredients of linaclotide. It is often used in constipation. eHealthMe is studying from 24,086 Linzess users. Check the latest studies of Linzess.

What is Librax?

Librax has active ingredients of chlordiazepoxide hydrochloride; clidinium bromide. eHealthMe is studying from 660 Librax users. Check the latest studies of Librax.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 17, 2026

21 people who take Linzess and Librax together, and have interactions are studied.

What are the common drug interactions of Linzess and Librax, by gender? *:

female:

Diarrhoea
Headache (pain in head)
Abdominal pain upper
Dry mouth
Dyspnoea (difficult or laboured respiration)
Muscle spasms (muscle contraction)
Oral pain
Pain in extremity
Pain in jaw
Nausea (feeling of having an urge to vomit)

male:

Dyspepsia (indigestion)
Nausea (feeling of having an urge to vomit)
Pancreatitis relapsing
Pharyngitis streptococcal (inflammation of the pharynx caused by infection from. streptococcus)
Renal disorder (kidney disease)
Respiratory tract infection
Sinusitis (inflammation of sinus)
Abdominal pain
Abdominal pain lower
Disability

What are the common drug interactions of Linzess and Librax, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Anaphylactic reaction (serious allergic reaction)
Dyspnoea (difficult or laboured respiration)
Oropharyngeal discomfort (pain or irritation of oropharynx)
Pruritus (severe itching of the skin)
Urticaria (rash of round, red welts on the skin that itch intensely)

50-59:

Cystitis (inflammation of the wall of the bladder)
Fungal infection
Kidney infection
Urinary tract infection

60+:

Diarrhoea
Nausea (feeling of having an urge to vomit)
Anaemia (lack of blood)
Arthralgia (joint pain)
Back pain
Breast cancer
Cerebral disorder (brain disease)
Chronic kidney disease
Cough
Death

What are the existing conditions these people have? *

Irritable Bowel Syndrome: 4 people, 19.05%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 3 people, 14.29%
Nausea (feeling of having an urge to vomit): 3 people, 14.29%
Wheezing (a high-pitched whistling sound made while you breath): 2 people, 9.52%
Muscle Spasms (muscle contraction): 2 people, 9.52%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

Do you take Linzess and Librax?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously