Linzess and Mesalamine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Linzess (linaclotide) and Mesalamine (mesalamine). Common drug interactions include burning sensation among females and bronchitis among males.

The phase IV clinical study analyzes what interactions people have when they take Linzess and Mesalamine. It is created by eHealthMe based on reports of 46 people who take the same drugs from the FDA, and is updated regularly.

What is Linzess?

Linzess has active ingredients of linaclotide. It is often used in constipation. eHealthMe is studying from 24,086 Linzess users. Check the latest studies of Linzess.

What is Mesalamine?

Mesalamine has active ingredients of mesalamine. It is often used in ulcerative colitis. eHealthMe is studying from 28,053 Mesalamine users. Check the latest studies of Mesalamine.

On Jul, 13, 2026

46 people who take Linzess and Mesalamine together, and have interactions are studied.

Linzess and Mesalamine drug interactions.

What are the common drug interactions of Linzess and Mesalamine, by gender? *:

female:

Burning sensation
Erythema (redness of the skin)
Fatigue (feeling of tiredness)
Spinal osteoarthritis (joint cartilage loss in spine)
Infection
Maculopathy (a condition or disease of the macula, the small spot in the retina where vision is keenest)
Nonspecific reaction (unspecified reaction)
Abdominal discomfort
Arthropathy
Asthma

male:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Sinusitis (inflammation of sinus)
Hypokinesia (decreased bodily movement)
Palpitations (feelings or sensations that your heart is pounding or racing)
Pneumonia
Slow speech
Tooth infection
Tremor (trembling or shaking movements in one or more parts of your body)
Abdominal pain
Abdominal pain upper

What are the common drug interactions of Linzess and Mesalamine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Intervertebral disc protrusion (spinal disc protrusion)
Lung disorder (lung disease)

50-59:

Maculopathy (a condition or disease of the macula, the small spot in the retina where vision is keenest)
Blood sodium decreased
Gastroenteritis (inflammation of stomach and intestine)
Hepatic steatosis (fatty liver disease)
Hypoaesthesia (reduced sense of touch or sensation)
Rash

60+:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Sinusitis (inflammation of sinus)
Fall
Hypersensitivity
Hypokinesia (decreased bodily movement)
Palpitations (feelings or sensations that your heart is pounding or racing)
Pneumonia
Slow speech
Tooth infection
Tremor (trembling or shaking movements in one or more parts of your body)

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 9 people, 19.57%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 7 people, 15.22%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 13.04%
Nausea (feeling of having an urge to vomit): 5 people, 10.87%
High Blood Cholesterol: 5 people, 10.87%
Irritable Bowel Syndrome: 5 people, 10.87%
Migraine (headache): 5 people, 10.87%
Stress And Anxiety: 5 people, 10.87%
Pain: 5 people, 10.87%
Headache (pain in head): 4 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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