Linzess and Norvir drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Linzess (linaclotide) and Norvir (ritonavir). Common drug interactions include anxiety among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Linzess and Norvir. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Linzess?

Linzess has active ingredients of linaclotide. It is often used in constipation. eHealthMe is studying from 24,086 Linzess users. Check the latest studies of Linzess.

What is Norvir?

Norvir has active ingredients of ritonavir. It is often used in hiv infection. eHealthMe is studying from 24,973 Norvir users. Check the latest studies of Norvir.



On Jul, 05, 2026

19 people who take Linzess and Norvir together, and have interactions are studied.

Linzess and Norvir drug interactions.

What are the common drug interactions of Linzess and Norvir, by gender? *:

female:

  1. Anxiety
  2. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  3. Emotional distress
  4. Pain
  5. Osteoporosis (bones weak and more likely to break)
  6. Multiple fractures
  7. Depression
  8. Foot fracture
  9. Gait disturbance
  10. Chronic kidney disease

male:

  1. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  2. Anxiety
  3. Bone loss
  4. Cervical radiculopathy (disturbance of nerve function that causes pain in the upper body)
  5. Cervical spinal stenosis (narrowing of the spinal canal in the neck)
  6. Decreased activity
  7. Depression
  8. Drug ineffective
  9. Fracture
  10. Hip fracture

What are the common drug interactions of Linzess and Norvir, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Foot fracture
  2. Anxiety
  3. Bone density decreased
  4. Multiple fractures
  5. Osteoporosis (bones weak and more likely to break)
  6. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  7. Bone loss
  8. Chronic kidney disease
  9. Depression
  10. Emotional distress

50-59:

  1. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  2. Anxiety
  3. Quality of life decreased
  4. Back pain
  5. Bone density decreased
  6. Bone loss
  7. Foot fracture
  8. Pain in extremity
  9. Tibia fracture (fracture of lower leg bone)
  10. Bedridden

60+:

n/a

* Approximation only. Some reports may have incomplete information.

Do you take Linzess and Norvir?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Linzess and Norvir:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Linzess:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Norvir:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Linzess and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Norvir and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on linaclotide and ritonavir (the active ingredients of Linzess and Norvir, respectively), and Linzess and Norvir (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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