Linzess and Nuvaring drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Linzess (linaclotide) and Nuvaring (ethinyl estradiol; etonogestrel). Common drug interactions include fatigue among females.

The phase IV clinical study analyzes what interactions people have when they take Linzess and Nuvaring. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Linzess?

Linzess has active ingredients of linaclotide. It is often used in constipation. eHealthMe is studying from 24,086 Linzess users. Check the latest studies of Linzess.

What is Nuvaring?

Nuvaring has active ingredients of ethinyl estradiol; etonogestrel. It is often used in birth control. eHealthMe is studying from 28,730 Nuvaring users. Check the latest studies of Nuvaring.

On Jul, 12, 2026

35 people who take Linzess and Nuvaring together, and have interactions are studied.

What are the common drug interactions of Linzess and Nuvaring, by gender? *:

female:

Fatigue (feeling of tiredness)
Injury
Headache (pain in head)
Pain
Stress
Suicidal ideation
Abdominal discomfort
Abnormal behaviour
Alanine aminotransferase increased
Anaemia (lack of blood)

male:

n/a

What are the common drug interactions of Linzess and Nuvaring, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal pain upper
Blood pressure decreased
Cystitis noninfective (non-infectious inflammation of the wall of the bladder)
Dehydration (dryness resulting from the removal of water)
Device dislocation
Emotional distress
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Genital haemorrhage (bleeding from genital)
Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Injury

30-39:

Hypotension (abnormally low blood pressure)
Intervertebral disc protrusion (spinal disc protrusion)
Lymphoedema (localized fluid retention and tissue swelling)
Muscle spasms (muscle contraction)
Oedema peripheral (superficial swelling)
Pain in extremity
Pneumonia bacterial (pneumonia associated with bacterial infection)
Urinary tract infection
Abdominal discomfort
Abnormal behaviour

40-49:

Anxiety
Apnoea (suspension of external breathing)
Injury
Lipodystrophy acquired (a regional loss of subcutaneous adipose tissue which usually starts in the face, extends downward acquired)
Loss of employment
Mean cell haemoglobin concentration decreased (less concentration of haemoglobin in a given volume of packed red blood cells)
Myalgia (muscle pain)
Palpitations (feelings or sensations that your heart is pounding or racing)
Snoring
Somnolence (a state of near-sleep, a strong desire for sleep)

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 19 people, 54.29%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 8 people, 22.86%
Stress And Anxiety: 3 people, 8.57%
Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain): 3 people, 8.57%
Pain In Extremity: 2 people, 5.71%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 5.71%
Mood Swings (an extreme or rapid change in mood): 2 people, 5.71%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 2 people, 5.71%
Insomnia (sleeplessness): 2 people, 5.71%
Drowsiness: 2 people, 5.71%

* Approximation only. Some reports may have incomplete information.

Do you take Linzess and Nuvaring?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously